Abstract
Background
Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are the most frequent bariatric surgery procedures worldwide. In this prospective study, we examined the association of a genetic risk score (GRS) with loss of excess weight after bariatric surgery.
Methods
A total of forty-seven morbidly obese Greek patients who underwent SG (81%) or RYGB were recruited, followed up for 2 years and genotyped. Weight loss after surgery was reported as the percentage of excess weight that was lost (%EWL) at 12 and 24 months after surgery. A GRS was constructed based on previously BMI- and WHR-related single nucleotide polymorphisms (SNPs) that were found significantly correlated with weight loss after bariatric surgery in our population. The level of post-surgery %EWL after 12 and 24 months was estimated through two multiple linear regression models that considered the effects of relevant genetic risk variants.
Results
The first proposed model suggested that the predictor variables of GRS, age, and BMI had a significant effect on %EWL12m. GRS was significantly associated with %EWL12m, indicating a 4.618% decrease of %EWL12m per score unit. The second model indicated a positive correlation between %EWL24m and %EWL12m, suggesting that while post-surgery weight loss increased during the first 12 months, an increase was expected in the next 12 months as well. GRS was also significantly associated with %EWL24m, indicating approximately 3% decrease of %EWL24m per score unit.
Conclusion
GRS can be used in the future together with other preoperative parameters in order to predict the outcome of bariatric surgery.
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Acknowledgments
We thank University of Geneva Medical School in Switzerland, McGill University and Génome Québec Innovation Centre, and Bart’s and the London Genome Centre at Queen Mary, University of London, for the genotyping and technical support. We also thank all physicians of “Laiko” General Hospital, Athens, for their collaboration in patient recruitment and blood collecting and finally all patients for their consent and their trust.
Funding
This study was financially funded by program “THALES” which has been co-financed by the European Union (European Social Fund–ESF) and Greek national funds through the Operational Program “Education and Lifelong Learning” of the National Strategic Reference Framework (NSRF) (MIS 377123).
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The study was approved by the Bioethics Committee of Harokopio University of Athens (38073/13-07-2012), based on the Helsinki Declaration.
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Katsareli, E.A., Amerikanou, C., Rouskas, K. et al. A Genetic Risk Score for the Estimation of Weight Loss After Bariatric Surgery. OBES SURG 30, 1482–1490 (2020). https://doi.org/10.1007/s11695-019-04320-6
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DOI: https://doi.org/10.1007/s11695-019-04320-6