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Biliary Jejunostomy Might Improve Glucose in Type 2 Diabetes Patients

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Abstract

Purposes

Biliopancreatic diversion could improve type 2 diabetes mellitus. Our aim was to investigate the effects of biliary jejunostomy on the improvement of glucose.

Materials and Methods

Twenty-seven type 2 diabetes patients underwent biliary jejunostomy between January 2013 and January 2018 in our hospital and were followed up. Demographic data, operation details, body weight, food intake, effects on diabetes control, and biomedical parameters were collected and analyzed.

Results

As defined previously, 3 of 27 diabetes patients were “under control,” 8 patients were “in remission,” and 12 patients were “improved.” The fasting glucose decreased from 9.7 ± 2.1 mmol/L before surgery to 7.9 ± 1.8 mmol/L 12 months after surgery (P = 0.001). The level of hemoglobin A1c in these patients was 9.1 ± 2.3% before surgery, and it decreased to 7.2 ± 1.3% 12 months after surgery (P < 0.001). There was no significant difference in the body weight index (P = 0.78) or food intake (P = 0.18) between the time prior to surgery and 12 months afterward. The average level of total bile acids increased significantly after surgery, from 6.7 ± 2.2 μmol/L before surgery to 8.6 ± 2.9 μmol/L 12 months after surgery (P < 0.001).

Conclusions

Fasting glucose in type 2 diabetes patients was improved after biliary jejunostomy. Increasing bile acids levels might play an important role in the remission of type 2 diabetes.

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Funding

This study was funded by the National Natural Science Foundation of China (grant number 81400797/H0713).

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Author notes

  1. Ning Zhang and Weijie Chen contributed equally to this work.

Authors and Affiliations

  1. Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People’s Republic of China

    Ning Zhang, Weijie Chen, Wei Liu & Xiaodong He

Authors
  1. Ning Zhang
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  2. Weijie Chen
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  3. Haixin Yin
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  4. Wei Liu
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  5. Xiaodong He
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Contributions

Xiaodong He designed the study. Ning Zhang and Haixin Yin followed up patients and collected the data. Wei Liu analyzed the data, and Weijie Chen wrote the manuscript.

Corresponding author

Correspondence to Xiaodong He.

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The authors declare that they have no conflict(s) of interest. For this type of study, formal consent is not required.

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Zhang, N., Chen, W., Yin, H. et al. Biliary Jejunostomy Might Improve Glucose in Type 2 Diabetes Patients. OBES SURG 30, 1446–1451 (2020). https://doi.org/10.1007/s11695-019-04319-z

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