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Comparison of Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy on Weight Loss, Weight Regain, and Remission of Comorbidities: A 5 Years of Follow-up Study



This study was conducted to evaluate the amount of weight loss and weight regain and also remission rate of obesity-related comorbidities including diabetes mellitus (DM), hypertension (HTN), and dyslipidemia in patients who underwent LRYGB or LSG during 5 years of follow-up.


A total of 120 patients who underwent LRYGB or LSG from 2011 to 2013 were enrolled and followed-up for 5 years. Changes in weight, body mass index (BMI), percent weight loss (%WL), and percentage of excess weight loss (%EWL) were recorded.


%WL and %EWL were similar between two procedures at 1 year following operation. In patients who underwent LSG, %WL and %EWL were 24.6 ± 1.3% and 61.9 ± 3.5%, respectively, and in LRYGB were 30.4 ± 1.3% and 79.4 ± 3.6%, respectively, 5 years after surgery. Weight regain was 32.0% in LSG and 9.3% in LRYGB after 5 years. The remission rate of diabetes mellitus, hypertension, and dyslipidemia was 70%, 54%, and 100%, respectively, after 5 years of surgery.


Comparing the 5-year success rate of these two techniques, LRYGB seems to be superior to LSG, with lower weight regain and higher weight loss. The short- and long-term effects of two procedures on remission of comorbidities were comparable.

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The authors acknowledged Mrs. Roya Farid for critical editing of English grammar of the manuscript.

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Corresponding author

Correspondence to Mahdieh Golzarand.

Ethics declarations

The study protocol was approved by the Ethics Committee of Tehran University of Medical Sciences (No. 9311245004), and informed consent was obtained from all the participants.

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The authors declare that they have no conflict of interest.

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Toolabi, K., Sarkardeh, M., Vasigh, M. et al. Comparison of Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy on Weight Loss, Weight Regain, and Remission of Comorbidities: A 5 Years of Follow-up Study. OBES SURG 30, 440–445 (2020).

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  • Gastric bypass
  • Sleeve gastrectomy
  • Weight loss
  • Weight regain
  • Diabetes
  • Hypertension
  • Dylipidemia