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Short-Term Diabetes Remission Outcomes in Patients with BMI ≤ 30 kg/m2 Following Sleeve Gastrectomy

  • Jason Widjaja
  • Haixing Pan
  • Ponnie Robertlee Dolo
  • Libin Yao
  • Chao Li
  • Yong Shao
  • Xiaocheng ZhuEmail author
Original Contributions

Abstract

Background

Sleeve gastrectomy (SG) has become the most popular bariatric procedure. Although bariatric surgery is recommended for type 2 diabetes mellitus (T2DM) in Asian patients with BMI 27.5–32.4 kg/m2, reported evidences, especially following SG, are still lacking.

Methods

Patients’ data from June 2016 to June 2018 that underwent SG as primary surgery at our setting were analyzed. Patients with T2DM, without insulin use and BMI 27.5–30 kg/m2, were our main criteria. Preoperative and postoperative parameters were as such: age, BMI, T2DM duration, anti-diabetic medications, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), insulin, C-peptide, and homeostatic model assessment-insulin resistance (HOMA-IR). Follow-up duration was at 1, 3, 6, and 12 months.

Results

Eighteen patients (7 male and 11 female) were presented for this study. The mean age and diabetes duration were 46.3 ± 11.9 years and 31.8 ± 26.5 months, respectively. The mean preoperative vs postoperative 12-month assessment was as such: BMI 29.3 ± 0.9 vs 23.9 ± 0.9 kg/m2, FPG 8.4 ± 3.1 vs 5.6 ± 0.7 mmol/L, HbA1c 8.3 ± 1.8 vs 5.9 ± 0.7%, insulin 103.9 ± 47.4 vs 53.9 ± 13.1 pmol/L, C-peptide 1.90 ± 1.22 vs 1.08 ± 0.44 ng/ml, and HOMA-IR 5.5 ± 4.0 vs 1.9 ± 0.6, all reached statistical significance (p value < 0.05).

Conclusions

In short-term, and also under strict selection criteria, SG can result in both improvement and remission of T2DM in patients with BMI 27.5–30 kg/m2. Larger sample size and longer follow-up duration will be needed in the future.

Keywords

Bariatric surgery Sleeve gastrectomy Type 2 diabetes mellitus Low BMI Diabetes remission 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

For this retrospective study, additional formal consent is not required.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of General SurgeryThe Affiliated Hospital of Xuzhou Medical UniversityXuzhouPeople’s Republic of China

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