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Prophylactic Use of Enoxaparin in Adolescents During Bariatric Surgery—a Prospective Clinical Study

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Abstract

Introduction

Severe obesity predisposes youth to a higher risk of venous thromboembolism (VTE). This study evaluates a BMI-stratified prophylactic dosing regimen of enoxaparin in adolescents with severe obesity undergoing surgery.

Methods

Adolescents aged 12–20 years received prophylactic enoxaparin at 40 mg SC (for a BMI < 50 kg/m2) and 60 mg SC (for a BMI ≥ 50 kg/m2) every 12 h until discharge. Blood samples were drawn at pre-dose, 1, 2, 4, 6, and 12 h. Plasma Anti-Factor Xa (Anti-FXa) activity was used as a surrogate marker for enoxaparin pharmacokinetics.

Results

Ten female and two male obese adolescents (age range 14–19 years) had a mean BMI of 49.9 kg/m2 (38.4–58 kg/m2). Four patients had a BMI of less than 50 kg/m2 and received 40 mg enoxaparin, resulting in a mean dosage of 0.352 ± 0.070 mg/kg body weight. Eight patients were dosed with 60 mg enoxaparin every 12 h, resulting in a mean dosage of 0.395 ± 0.028 mg/kg. Peak plasma anti-FXa activity (Cmax) ranged from 0.14 to 0.30 IU/mL, median Cmax was 0.205 IU/mL. Median Tmax was 5.67 h (range 3.78–7.52 h). Median AUCi was 1.00 h IU/mL (range 0.42–1.67 h IU/mL). Ten out of 12 patients (83%) reached the primary endpoint with anti-FXa activity in the range for VTE prevention (0.1–0.3 IU/mL).

Conclusions

Our dosing scheme of 40 mg vs. 60 mg enoxaparin stratified according to BMI proved to be effective in reaching prophylactic anti-FXa activity in 83% of adolescent patients.

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Author information

Correspondence to Janelle D. Vaughns.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

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Informed assent and consent was obtained from all individual participants and their parents in this study.

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Vaughns, J.D., Ziesenitz, V.C., Williams, E.F. et al. Prophylactic Use of Enoxaparin in Adolescents During Bariatric Surgery—a Prospective Clinical Study. OBES SURG 30, 63–68 (2020) doi:10.1007/s11695-019-04135-5

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Keywords

  • Enoxaparin
  • LMWH
  • Obesity
  • Adolescents
  • Bariatric surgery
  • VTE prophylaxis