Propofol Sedation for Intragastric Balloon Removal: Looking for the Optimal Body Weight Descriptor
- 14 Downloads
Sedation is considered as a prerequisite for the safe and effective conclusion of Bioenterics Intragastric Balloon (BIB) removal (our aim was to ascertain the most appropriate body size scalars for propofol dosing and assess the efficacy and safety of a sedative approach involving the infusion of propofol for BIB removal.
Retrospective analysis of prospectively collected data of 414 adults scheduled to undergo BIB removal. Our primary end-point was to delineate the relationship between propofol dosing and body size descriptors namely body mass index, total body weight, ideal body weight, lean body weight (LBW) and normalized LBW. Sedative efficacy of this practice, anesthesia or procedural-related adverse events and patients’ satisfaction level served as secondary outcome parameters.
Propofol dose (mg/kg/min) was positively related to all body weight descriptors in an important manner (p < 0.001). Among them, LBW was singled out as the body size descriptor to best capture the appropriate needs of propofol (R2 = 0.432; p = 0.000). Hypoxemia, hemodynamic compromise, gastroesophageal reflux or moderate movement occurred rarely; all of them were readily reversed. The majority of participants had no recollection of the noxious phase of the procedure or declared at least adequately satisfied from the experience (84% and 95%, respectively).
LBW could serve as relatively more accurate dosing scalar compared to actual or ideal body weight descriptors, in obese individuals undergoing BIB removal under propofol sedation. The conscious/deep sedation based on propofol infusion emerges as a feasible and efficacious sedative approach for this procedure.
KeywordsObesity Intragastric balloon Propofol Body weight scalar
No funding was received for this study; no corporate sponsor was involved.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
• All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
• For this type of study, formal consent is not required.
- 21.Likert R. A technique for the measurement of attitudes. Arch Psychol. 1932;22:1–55.Google Scholar
- 40.Leslie K, Clavisi O, Hargrove J. Target-controlled infusion versus manually-controlled infusion of propofol for general anaesthesia or sedation in adults. Cochrane Database Syst Rev. 2008;3:CD006059.Google Scholar
- 41.Laosuwan S, Pongruekdee S, Thaharavanich R. Comparison of effective-site target controlled infusion and manually controlled infusion of propofol for sedation during spinal anesthesia. J Med Assoc Thail. 2011;94:965–71.Google Scholar