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Comparative Study of Resting Metabolic Rate and Plasma Amino Acid Profile in Patients Who Underwent Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy: 6-Month Follow-up Study

  • Mahdieh Golzarand
  • Karamollah ToolabiEmail author
  • Mehdi Hedayati
  • Kamal Azam
  • Masoomeh Douraghi
  • Kurosh DjafarianEmail author
Original Contributions
  • 51 Downloads

Abstract

Purpose

Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) are the most common techniques for treatment of morbid obesity. However, a few studies have compared the energy expenditure and plasma amino acid profile after LRYGB and LSG. The present study was conducted to assess the resting metabolic rate (RMR) and plasma amino acid profile in obese patients who underwent LRYGB and LSG before and 6 months after the surgery in order to compare these changes from baseline between the two procedures.

Materials and Methods

Forty-three adult obese patients participated in this study (LRYGB = 22 and LSG = 21) and were followed up for 6 months. RMR was measured by indirect calorimetry. The plasma amino acid profile was determined using high-performance liquid chromatography (HPLC).

Results

Mean percent excess weight loss (%WL) were 22.8 ± 4.5% and 23.3 ± 5.7% in LRYGB and LSG, respectively. RMR reduced significantly from baseline by − 459 ± 202 kcal/day in LRYGB and − 500 ± 262 kcal/day in LSG. RMR reduced beyond the expected decrease in both procedures. A decreasing trend was observed in the plasma concentration of branched-chain amino acids (BCAA), aromatic amino acids (AAA), and amino acid index (AAI) in both techniques. There was no significant difference in weight, RMR analysis, and amino acid change from baseline between LRYGB and LSG.

Conclusion

Our results showed that the effects of LRYGB and LSG on RMR and amino acid profile were comparable.

Keywords

Gastric bypass Sleeve gastrectomy Resting metabolic rate Amino acid profile Branched-chain amino acid Energy expenditure 

Notes

Acknowledgments

The authors acknowledge Mrs. Roya Farid for critical editing of English grammar of the manuscript.

Compliance with Ethical Standards

The study protocol was approved by the Ethics Committee of Tehran University of Medical Sciences and written consent was obtained from all patients.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Clinical Nutrition, School of Nutritional Sciences and DieteticsTehran University of Medical SciencesTehranIran
  2. 2.Department of Surgery, Imam Khomeini HospitalTehran University of Medical SciencesTehranIran
  3. 3.Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran
  4. 4.Department of Epidemiology and Biostatistics, School of Public HealthTehran University of Medical SciencesTehranIran
  5. 5.Department of Pathobiology, School of Public HealthTehran University of Medical SciencesTehranIran

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