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Bone Metabolism in Adolescents and Adults Undergoing Roux-En-Y Gastric Bypass: a Comparative Study

  • Débora Santos
  • Tais Lopes
  • Patrícia Jesus
  • Sabrina CruzEmail author
  • Adryana Cordeiro
  • Silvia Pereira
  • Carlos Saboya
  • Andréa Ramalho
Original Contributions

Abstract

Objective

To compare the bone metabolism of adolescents and adults with obesity before undergoing a Roux-en-Y gastric bypass (RYGB) and 6 and 12 months after the surgery.

Materials and Methods

Adolescents (G1) and adults (G2) with obesity assessed before (T0), six (T1), and 12 months after (T2) RYGB. Sun exposure, serum concentrations of 25(OH)D, calcium, phosphorous, magnesium, zinc, alkaline phosphatase, parathyroid hormone (PTH), and bone mineral density (BMD) were evaluated.

Results

Sixty adolescents and 60 adults were assessed. At T0, there was no significant difference between the groups’ serum 25(OH)D levels (G1 21.87 + 7.52 ng/mL, G2 21.73 + 7.60 ng/mL, p = 0.94) or sun exposure (G1 17 ± 2.0 min/day, G2 13.2 ± 5.2 min/day, p = 0.85). G1 had high levels of inadequacy of calcium (66.7%), phosphorous (80.0%), and zinc (18.3%) at T0 and had a significant fall in their 25(OH)D (p < 0.01) and magnesium (p < 0.01) levels from T1 to T2. G2 saw a significant lowering of their serum zinc levels from T0 to T1 and T2 (T1 p < 0.01; T2 p < 0.01). In both groups, there was a significant rise in PTH from T1 to T2 (G1 p = 0.04, G2 p = 0.02) and from T0 to T2 (G1 and G2 p < 0.01). In G2, 40.4% of individuals with osteopenia and osteoporosis presented inadequacy of 25(OH)D.

Conclusion

RYGB was found to worsen the inadequacy of micronutrients related to bone metabolism and was associated with secondary hyperparathyroidism and low BMD values, especially among the adolescents. The irreversible damaging effects of obesity on bone metabolism can occur in adolescence.

Keywords

Obesity Adolescents Adults Bone metabolism Roux-en-Y gastric bypass 

Notes

Funding Information

The different stages of this study are funded by the Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Researcher of the Center for Research on Micronutrients (NPqM) of the Institute of Nutrition Josué de Castro of Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBrazil
  2. 2.School of Medicine at Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBrazil
  3. 3.Multidisciplinary Center for Bariatric and Metabolic SurgerySchool of Medicine of Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBrazil
  4. 4.Researcher of the NPqM at Federal University of Rio de Janeiro(UFRJ)Rio de JaneiroBrazil
  5. 5.Federal University of São Paulo (UNIFESP)São PauloBrazil
  6. 6.Department of Social and Applied Nutrition of the Institute of Nutrition at UFRJ. Coordinator of the Center for Research on Micronutrients (NPqM) of the Institute of Nutrition Josué de Castro of UFRJRio de JaneiroBrazil

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