Adequate Multivitamin Supplementation after Roux-En-Y Gastric Bypass Results in a Decrease of National Health Care Costs: a Cost-Effectiveness Analysis

A Correction to this article was published on 18 March 2019

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Patients with morbid obesity undergoing metabolic surgery are prone to develop vitamin and mineral deficiencies, which may worsen in time. In order to prevent these deficiencies after metabolic surgery, all patients are advised to take daily multivitamin supplementation. The aim of the study was to assess the cost-effectiveness of specially developed multivitamins (WLS Forte®) for metabolic surgery and over-the-counter (standard) multivitamin supplementation (sMVS).


This cost-effectiveness analysis was preformed alongside an RCT for the Netherlands. Between June 2011 and March 2012, a total of 148 patients were randomized to one tablet daily of either WLS Forte® or sMVS. The patients were followed for 12 months. Data on costs within the health sector and outside the health sector were collected. The primary outcome is financial and logistic advantages, in terms of less patient visits to the outpatient department and the relevant costs to the employer due to absenteeism.


In total, 10 (14%) patients in the WLS Forte® group versus 23 (30%) patients in the sMVS group developed a deficiency. The costs for the WLS forte® supplement were €38 versus €23 for sMVS. Additional return visits and associated costs for medical staff were the largest costs, up to 43% in the sMVS group. Total costs for supplementation with sMVS were €243 versus €134 for WLS Forte®.


Preventing deficiencies with WLS Forte® seem initially more expensive than sMVS. However, treatment with WLS Forte® resulted in less vitamin and mineral deficiencies, which eventually resulted in less overall costs.

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  • 18 March 2019

    In the original article, there are some incorrect data in the “Results” section of the Abstract


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We would like to thank M.M. Rovers (M.D. Ph.D.) for her contribution to our work.


this research did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sector. For the initial randomized controlled trial, capsules and placebo capsules were provided free of charge.

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Correspondence to Jens Homan.

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Conflict of Interest

IMCJ, FJB, and EOA are consults for FitForMe™, Rotterdam, the Netherlands. All the other authors have nothing to declare.

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Informed consent was obtained from all individual participants included in the study.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Homan, J., Schijns, W., Janssen, I.M.C. et al. Adequate Multivitamin Supplementation after Roux-En-Y Gastric Bypass Results in a Decrease of National Health Care Costs: a Cost-Effectiveness Analysis. OBES SURG 29, 1638–1643 (2019).

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  • Cost-effectiveness
  • Multivitamin supplementation
  • Morbid obesity
  • Roux-en-Y gastric bypass