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Improving Weight Loss by Combination of Two Temporary Antiobesity Treatments

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Abstract

Background

It is generally accepted that the efficacy with an intragastric balloon decreases after the first 4 months of treatment. Aim of this study is to evaluate if the association of a very low-calorie ketogenic diet (VLCKD) can improve the results in terms of weight loss parameters and co-morbidities, as compared to usually prescribed low-calorie diet (LCD).

Methods

For the present study (January 2016–June 2017), 80 patients (20 M/60 F, mean age 37.8 ± 6.1 years; excess weight 56 ± 10 kg; mean BMI 37.2 ± 3.8 kg/m2) underwent Orbera positioning. After 4 months, they were randomized into two groups according to the type of treatment: group A (Bioenterics intragastric balloon – Orbera + VLCKD) (n = 40), and group B (Orbera + LCD) (n = 40).

Results

All patients completed the study with good adherence to diet therapy treatment allocation. After the 6-month treatment period, at time of Orbera removal, mean weight loss was 19 kg and 12 kg in groups A and B respectively (p < 0.05). Mean BMI was 28.9 ± 2.8 and 31.6 ± 3.1 kg/m2 (p < 0.05), and %EWL was 33.1 ± 3.3 and 21.1 ± 2.9 (p < 0.05) in groups A and B respectively. During the last 2 months in group A, the mean weight loss was 8 kg, while in Group B, the main weight loss was 3 kg (p < 0.001). The VLCKD treatment induced a more significant reduction of major comorbidities related to metabolic syndrome.

Conclusions

This study clearly indicates the efficacy of the prescription of very low-calorie ketogenic diet improving the efficacy of intragastric balloon positioning.

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Authors and Affiliations

  1. Department of Surgical Sciences, Surgical Endoscopy Unit, La Sapienza University of Rome, Rome, Italy

    Alfredo Genco, Giovanni Casella, Emanuele Soricelli, Giovanni Baglio & Massimo Monti

  2. Department of Experimental Medicine-Medical Physiopathology, Food Science and Endocrinology Section, Sapienza University of Rome, Rome, Italy

    Roberta Ienca, Ilaria Ernesti, Sabrina Bresciani & Stefania Mariani

  3. Endoscopy Unit, Humanitas Hosp, Milan, Italy

    Roberta Maselli

  4. ASLNA3 SUD, DS56, UOML, Torre Annunziata, Naples, Italy

    Michele Lorenzo

Authors
  1. Alfredo Genco
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  2. Roberta Ienca
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  3. Ilaria Ernesti
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  4. Roberta Maselli
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  5. Giovanni Casella
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  6. Sabrina Bresciani
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  7. Stefania Mariani
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  8. Emanuele Soricelli
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  9. Giovanni Baglio
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  10. Michele Lorenzo
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  11. Massimo Monti
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Corresponding author

Correspondence to Michele Lorenzo.

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The authors declare that they have no competing interests.

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Genco, A., Ienca, R., Ernesti, I. et al. Improving Weight Loss by Combination of Two Temporary Antiobesity Treatments. OBES SURG 28, 3733–3737 (2018). https://doi.org/10.1007/s11695-018-3448-9

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  • DOI: https://doi.org/10.1007/s11695-018-3448-9

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