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The Effectiveness of Endoscopic Gastroplasty for Obesity Treatment According to FDA Thresholds: Systematic Review and Meta-Analysis Based on Randomized Controlled Trials

  • Antonio Coutinho Madruga-Neto
  • Wanderley Marques Bernardo
  • Diogo Turiani Hourneaux de Moura
  • Vitor Ottoboni Brunaldi
  • Rafael Krieger Martins
  • Iatagan Rocha Josino
  • Eduardo Turiani Hourneaux de Moura
  • Thiago Ferreira de Souza
  • Marco Aurélio Santo
  • Eduardo Guimarães Hourneaux de Moura
Review Article

Abstract

Endoscopic bariatric therapies (EBTs) are promising alternatives to conventional surgery for obesity. The aim of this study is to compare efficacy and safety through a systematic review and meta-analysis of the endoscopic gastroplasty techniques versus conservative treatment. We searched MEDLINE, EMBASE, Cochrane CENTRAL, Lilacs/Bireme. Randomized controlled trials (RCTs) enrolling obese patients comparing endoscopic gastroplasty to sham or diet/exercise were considered eligible. Among 6014 records, three RCTs were selected for meta-analysis. The total sample was 459 patients (312 EBTs vs 147 control). Mean total body weight loss in the intervention group (IG) was 4.8% higher than the control group (CG) at 12 months (p = 0.01). The IG responder rate was 44.31% at 12 months. Therefore, the endoscopic gastroplasty is more effective than conservative therapies but do not achieve FDA thresholds.

Keywords

Obesity Gastroplasty Endoscopy Endoluminal therapy Endoscopic therapy Endoscopic suture Systematic review Meta-analysis 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval Statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent Statement

Does not apply.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Antonio Coutinho Madruga-Neto
    • 1
  • Wanderley Marques Bernardo
    • 1
  • Diogo Turiani Hourneaux de Moura
    • 1
  • Vitor Ottoboni Brunaldi
    • 1
  • Rafael Krieger Martins
    • 1
  • Iatagan Rocha Josino
    • 1
  • Eduardo Turiani Hourneaux de Moura
    • 1
  • Thiago Ferreira de Souza
    • 1
  • Marco Aurélio Santo
    • 2
  • Eduardo Guimarães Hourneaux de Moura
    • 1
  1. 1.Gastrointestinal Endoscopy Unit, Hospital das ClínicasUniversity of São Paulo Medical SchoolSão PauloBrazil
  2. 2.Bariatric and Metabolic Surgery Unit, Hospital das ClínicasUniversity of São Paulo Medical SchoolSão PauloBrazil

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