The Effectiveness of Endoscopic Gastroplasty for Obesity Treatment According to FDA Thresholds: Systematic Review and Meta-Analysis Based on Randomized Controlled Trials
Endoscopic bariatric therapies (EBTs) are promising alternatives to conventional surgery for obesity. The aim of this study is to compare efficacy and safety through a systematic review and meta-analysis of the endoscopic gastroplasty techniques versus conservative treatment. We searched MEDLINE, EMBASE, Cochrane CENTRAL, Lilacs/Bireme. Randomized controlled trials (RCTs) enrolling obese patients comparing endoscopic gastroplasty to sham or diet/exercise were considered eligible. Among 6014 records, three RCTs were selected for meta-analysis. The total sample was 459 patients (312 EBTs vs 147 control). Mean total body weight loss in the intervention group (IG) was 4.8% higher than the control group (CG) at 12 months (p = 0.01). The IG responder rate was 44.31% at 12 months. Therefore, the endoscopic gastroplasty is more effective than conservative therapies but do not achieve FDA thresholds.
KeywordsObesity Gastroplasty Endoscopy Endoluminal therapy Endoscopic therapy Endoscopic suture Systematic review Meta-analysis
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Ethical Approval Statement
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed Consent Statement
Does not apply.
- 1.Ogden CL, Carroll MD, Fryar CD, Flegal KM. Prevalence of obesity among adults and youth: United States, 2011-2014. NCHS Data Brief. 2015(219):1–8.Google Scholar
- 3.Organization WH. Guideline: sugars intake for adults and children. Geneva. 2015.Google Scholar
- 19.Jonnalagadda SS, Gupta N, Eagon JC. Preliminary results of a randomized, blinded, sham-controlled trial of transoral gastroplasty for the treatment of morbid obesity. In: Gastroenterology, editor. Digestive Diease Week 2012, DDW 2012; San Diego, CA, United States: Gastroenterology; 2012. p. S78.Google Scholar
- 26.Kenney JF, Keepping ES. Standard Error of the Mean. 2nd edition. Princeton, NJ. 1951.Google Scholar
- 31.Brazilian Association for Studies on Obesity and Metabolic Syndrome. Brazilian Obesity Guideline 2016. 4 ed. São Saulo/SP. 2016.Google Scholar