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Obesity Surgery

, Volume 28, Issue 6, pp 1797–1802 | Cite as

Left Gastric Artery Embolisation for the Treatment of Obesity: a Systematic Review

  • Ali Kordzadeh
  • Bruno Lorenzi
  • Muhammad A. Hanif
  • Alexandros Charalabopoulos
New Concept
  • 166 Downloads

Abstract

Background

Endovascular left gastric artery (LGA) embolisation has gained significant attention in the treatment of obesity/morbid obesity and reduction of ghrelin. The objective of this systematic review is to evaluate the recent literature, strengths, limitations and practical aspects of this new procedure in combination with its physiological and anatomical paradigm.

Methods

A systematic electronic search of literature from 1966 to June 2017 in Medline, CINHAL, Embase, Scopus and Cochrane library in English language and adult subjects was conducted. This search was conducted in accordance with Preferred Reporting in Systematic Review and Meta-Analysis (PRISMA) guidelines. Quality assessment of the articles was performed, using Oxford critical appraisal skills programme (CASP), and their recommendation for practice was examined through National Institute for health Care Excellence (NICE). Inter-related reliability (Cronbach’s Alpha) was assessed between the two independent reviewers.

Results

A total of n = 62 individuals were subjected to LGA embolisation. At 1–3 months, 7–11% and, at 12 months, 2% weight reduction was associated with ghrelin concentration reduction of 36% at 6 months. There was Haemoglobin A1c reduction (7.4 to 6.3%) and improved quality of life (SF-36 questionnaire) at 6 months (9.5 points) (range, 3.2–17.2). Despite immediate epigastric pain and mucosal ulceration, no long-term adverse outcome was identified. The overall length of stay was 2–3 days.

Conclusions

The outcome of this review (level of evidence 3) suggests LGA embolisation is feasible and effective and perhaps a safe procedure in the treatment of obesity and reduction of ghrelin. However, further trials are highly advocated.

Keywords

Left gastric artery (LGA) Gastric artery embolisation (GAE) Obesity Morbid obesity Bariatrics Systematic review 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Informed Consent

Not applicable

Statement of Human and Animal Rights

Not applicable

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Vascular, Endovascular and Renal AccessMid Essex Hospitals Services NHS TrustBroomfieldUK
  2. 2.Broomfield HospitalEssexUK
  3. 3.Department of General and Upper Gastrointestinal Surgery, Regional Oesophagogastric CentreMid Essex Hospitals Services NHS TrustBroomfieldUK
  4. 4.Department of Interventional RadiologyMid Essex Hospitals Services NHS TrustBroomfieldUK

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