Effect of the EndoBarrier Device: a 4-Year Follow-up of a Multicenter Randomized Clinical Trial
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To evaluate the long-term effect of the duodenal-jejunal bypass liner (DJBL) on weight loss and glycemic control.
Data on the long-term effect of DJBL treatment is still missing.
From 2010 to 2012, 29 patients were treated with the DJBL at center A and center B, as part of a multicenter randomized controlled trial. Prior to implantation and after removal of the DJBL, all patients underwent standardized physical examination and blood sampling. Four years after removal of the DJBL, included patients underwent standardized physical examination and blood sampling as previously performed during the initial study.
Out of the 29 patients, 15 patients were eligible for follow-up with a median duration of 42 months. Five patients had successfully received additional bariatric surgery. Four years after explantation of the DJBL, median weight in these 15 patients was 102.0 kg (IQR 94.0–124.6), which was not statistically significantly different from the 106.1 kg at baseline (IQR 99.0–128.4). Median BMI changed from 33.1 kg/m2 (IQR 32.3–38.5) at baseline to 33.7 kg/m2 (IQR 31.2–36.9) after follow-up. Patients had a TWL of 2.2% (IQR − 1.3–5.6) compared to baseline weight. None of the parameters were significantly different after follow-up compared to baseline.
The effect of weight reduction of initial DJBL treatment seems to be diminished after 4 years of follow-up. However, larger prospective studies with long-term follow-up need to be conducted in the future.
KeywordsObesity Abdominal surgery Duodenal-jejunal bypass liner Type 2 diabetes mellitus
Compliance with Ethical Standards
Conflict of Interest
Author 1 has no conflict of interest or financial ties to disclose.
Author 2 has no conflict of interest or financial ties to disclose.
Author 3 has no conflict of interest or financial ties to disclose.
Author 4 reports to have received grants from GI Dynamics and personal fees from GI Dynamics and is a member of the scientific advisory board of GI Dynamics since February 2017.
Author 5 has no conflict of interest or financial ties to disclose.
- 1.Health and Social Care Information Centre LS. Statistics on Obesity. England: Physical Activity and Diet; 2013. NHS, 2013 9 may 2013. Report No.: 2Google Scholar
- 3.Schiller JS, Lucas JW, Ward BW, Peregoy JA. Summary health statistics for U.S. adults: National Health Interview Survey, 2010. Vital Health Stat 10. Data from the National Health Survey. 2012;(252):1–207.Google Scholar
- 7.Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient--2013 update: cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity. 2013;21(Suppl 1):S1–27.CrossRefGoogle Scholar
- 12.van Rijn S, Roebroek YG, Masclee AA, et al. Structural endoscopic techniques to treat obesity: a review. Surg Technol Int. 2015;26:84–91.Google Scholar
- 14.Betzel B, Homan J, Aarts EO, Janssen IM, de Boer H, Wahab PJ, et al. Weight reduction and improvement in diabetes by the duodenal-jejunal bypass liner: a 198 patient cohort study. Surg Endosc. 2016.Google Scholar