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Bariatric Surgery can Reduce Albuminuria in Patients with Severe Obesity and Normal Kidney Function by Reducing Systemic Inflammation

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Abstract

Background

Obesity causes renal problems including albuminuria. Bariatric surgery (BS) improves albuminuria. We investigated whether albuminuria is reduced by weight loss per se or by improved systemic inflammation induced by weight loss after BS.

Methods

Patients older than 18 years who received BS in Soonchunhyang University Hospital from 01 January 2011 to 31 December 2011 were included. Other inclusion criteria included body mass index (BMI) ≥ 30 kg/m2, creatinine level ≤ 1.0 mg/dL, and no overt proteinuria (trace amount or undetectable by dipstick). The patients were followed at 1 and 6 months after BS.

Results

Forty-three patients were analyzed. Three patients were men, 10 patients had diabetes, and 12 patients had hypertension. All patients had normal renal function (creatinine ≤ 1.0 mg/dL), and estimated glomerular filtration rate was 115.7 ± 16.5 mL/min/1.73 m2. There were significant reductions in body weight, BMI, high-sensitivity C-reactive protein (hs-CRP), and urine albumin-to-creatinine ratio (ACR). There were positive correlations between delta hs-CRP and delta body weight (r = 0.349, p = 0.043) or delta body mass index (BMI, r = 0.362, p = 0.035); between hs-CRP and body weight (r = 0.374, p = 0.001), BMI (r = 0.431, p < 0.001). Multivariate analysis using a linear mixed model demonstrated that hs-CRP (β = 0.5364, p = 0.026) was an independent risk factor affecting ACR.

Conclusions

Our study suggests that BS can reduce albuminuria in patients with severe obesity and normal kidney function by reducing systemic inflammation.

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Acknowledgments

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1A6A1A03032522) and Soonchunhyang University Research Fund.

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Authors and Affiliations

  1. Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, 31 Soonchunhyang 6-gil, Cheonan, 31151, South Korea

    Samel Park, Chi-young Choi, Nam-Jun Cho, Hyo-Wook Gil & Eun Young Lee

  2. Department of Surgery, Soonchunhyang University Seoul Hospital, Seoul, South Korea

    Yong Jin Kim

Authors
  1. Samel Park
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  2. Yong Jin Kim
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  3. Chi-young Choi
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Corresponding author

Correspondence to Eun Young Lee.

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Conflict of Interest

All authors declare that they have no conflicts of interest.

Ethical Statement and Consent Statement

The study protocol was approved by the Institutional Review Board of Soonchunhyang University Cheonan Hospital (IRB No. SCHCA_IRB_2011-78). All patients provided their written informed consent.

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Park, S., Kim, Y.J., Choi, Cy. et al. Bariatric Surgery can Reduce Albuminuria in Patients with Severe Obesity and Normal Kidney Function by Reducing Systemic Inflammation. OBES SURG 28, 831–837 (2018). https://doi.org/10.1007/s11695-017-2940-y

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  • DOI: https://doi.org/10.1007/s11695-017-2940-y

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