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Adipocyte Size and Leptin Receptor Expression in Human Subcutaneous Adipose Tissue After Roux-en-Y Gastric Bypass

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Abstract

The molecular mechanisms implicated in pronounced weight loss and metabolic benefits after bariatric surgery are still unknown. Adipocyte phenotype and metabolism have not been entirely explored. However, some features of adipocyte function have been studied, such as adipocyte size and inflammation, which are both reduced after bariatric surgery. Adipocyte fat metabolism, which is partly regulated by leptin, is likely modified, since adipocyte area is decreased. Here, we show that leptin receptor expression is increased, while adipocyte size is decreased 8 months after Roux-en-Y gastric bypass. Thus, adipocyte function is possibly modified by improved leptin signaling after bariatric surgery.

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Acknowledgements

Research grant from HIMFG (HIM-2015-052-ssa1219) in part funded this study.

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Authors and Affiliations

  1. Clínica de Obesidad y Cirugía Bariátrica, Hospital General “Dr. Manuel Gea González”, Mexico City, Mexico

    Martha Tamez & Victoria Ramos-Barragan

  2. Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico

    Patricia Mendoza-Lorenzo

  3. Departamento de Cirugía Endoscópica y Endoscopía Gastrointestinal, Hospital General “Dr. Manuel Gea González”, Mexico City, Mexico

    Pablo Arrieta-Joffe, Sergio López-Martínez, Martín E. Rojano-Rodríguez & Mucio Moreno-Portillo

  4. Laboratorio de Enfermedades Metabólicas: Obesidad y Diabetes, Hospital Infantil de México “Federico Gómez”, Dr. Marquez 162, Col. Doctores, Del. Cuauhtémoc, 06720, Mexico City, Mexico

    María E. Frigolet

Authors
  1. Martha Tamez
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  2. Victoria Ramos-Barragan
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  3. Patricia Mendoza-Lorenzo
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  4. Pablo Arrieta-Joffe
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  5. Sergio López-Martínez
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  6. Martín E. Rojano-Rodríguez
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  7. Mucio Moreno-Portillo
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  8. María E. Frigolet
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Corresponding author

Correspondence to María E. Frigolet.

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Tamez, M., Ramos-Barragan, V., Mendoza-Lorenzo, P. et al. Adipocyte Size and Leptin Receptor Expression in Human Subcutaneous Adipose Tissue After Roux-en-Y Gastric Bypass. OBES SURG 27, 3330–3332 (2017). https://doi.org/10.1007/s11695-017-2930-0

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  • DOI: https://doi.org/10.1007/s11695-017-2930-0

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