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In-Hospital Mortality and Post-Surgical Complications Among Cancer Patients with Metabolic Syndrome

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Abstract

Background

Metabolic syndrome (MetS) is an important etiologic and prognostic factor for cancer, but few studies have assessed hospitalization outcomes among patients with both conditions.

Methods

Data was obtained from the Healthcare Cost and Utilization project Nationwide Inpatient Sample (HCUP-NIS). Study variables were assessed using ICD-9 codes on adults aged 40 years and over admitted to a US hospital between 2007 and 2011 with primary diagnosis of either breast, colorectal, or prostate cancer. We examined in-hospital mortality, post-surgical complications, and discharge disposition among cancer patients with MetS and compared with non-MetS patients.

Results

Hospitalized breast (OR: 0.31, 95% CI: 0.20–0.46), colorectal (OR: 0.41, 95% CI: 0.35–0.49), and prostate (OR: 0.28, 95% CI: 0.16–0.49) cancer patients with MetS had significantly reduced odds of in-hospital mortality. The odds of post-surgical complications among breast (OR: 1.20, 95% CI: 1.03–1.39) and prostate (OR: 1.22, 95% CI: 1.09–1.37) cancer patients with MetS were higher, but lower by 7% among colorectal cancer patients with MetS. Additionally, breast (OR: 1.21, 95% CI: 1.11–1.32) and colorectal (OR: 1.06, 95% CI: 1.01–1.11) cancer patients with MetS had significantly higher odds for discharge to a skilled nursing facility compared with those without MetS, but this was not statistically significant among prostate cancer patients.

Conclusions

Adverse health outcomes were significantly higher among hospitalized patients with a primary diagnosis of cancer and MetS. Future studies are needed to identify clinical strategies for detecting and managing patients with MetS to reduce the likelihood of poor inpatient outcomes.

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Funding

This study was funded by grant K01TW010271 from the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agency.

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Authors and Affiliations

  1. Department of Epidemiology, University of Alabama at Birmingham, 1720 2nd Ave S, Birmingham, AL, 35294-0022, USA

    Tomi Akinyemiju & Swati Sakhuja

  2. Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA

    Tomi Akinyemiju

  3. Department of Epidemiology, University of Kentucky, 800 Rose Street, Lexington, KY, 40508, USA

    Tomi Akinyemiju

  4. University of Northern Colorado Cancer Rehabilitation Institute, Greeley, CO, USA

    Neomi Vin-Raviv

  5. School of Social Work, College of Health and Human Sciences, Colorado State University, Fort Collins, CO, USA

    Neomi Vin-Raviv

Authors
  1. Tomi Akinyemiju
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Corresponding author

Correspondence to Tomi Akinyemiju.

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Ethics and Consent Statement

This study was considered exempt by the Institutional Review Board at the University of Alabama at Birmingham, as the HCUP-NIS database is a publicly available and non-identifiable data source.

Conflicts of Interest

The authors declare that they have no conflict of interest.

Statement of Informed Consent

This study used the HCUP-NIS database which is a publicly available and non-identifiable secondary data source. For this type of study, additional informed consent is not required.

Statement of Human and Animal Rights

This article does not contain any experiments with human participants or animals performed by any of the authors.

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Akinyemiju, T., Sakhuja, S. & Vin-Raviv, N. In-Hospital Mortality and Post-Surgical Complications Among Cancer Patients with Metabolic Syndrome. OBES SURG 28, 683–692 (2018). https://doi.org/10.1007/s11695-017-2900-6

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  • DOI: https://doi.org/10.1007/s11695-017-2900-6

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