Abstract
Background
Morpho-functional modifications of the gastric remnant after Roux-en-Y gastric bypass (RYGB) have not been completely defined, due to its inaccessibility for bioptic mapping. The aim of the study is to evaluate such modifications using Gastropanel®, a non-invasive blood test cross-checking four gastric biomarkers, able to provide a snapshot of mucosa conditions.
Subjects and Methods
Twenty-four women undergoing RYGB were prospectively enrolled. Gastropanel® parameters (pepsinogens, Gastrin-17 and immunoglobulins against Helicobacter pylori), biometrical/clinical data were collected preoperatively and at 6-months follow-up.
Results
All parameters showed significant reduction (p < 0.05). Pepsinogen I reduction correlated with BMI percent decrease.
Conclusions
The exclusion of food transit is responsible for significant drop in gastric output, hardly representing a risk factor in the remnant carcinogenesis, being unexposed to alimentary carcinogenic agents.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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The authors declare that they have no conflicts of interest.
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Informed consent was obtained from all individual participants included in the study.
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Marchesi, F., Tartamella, F., De Sario, G. et al. The Sleeping Remnant. Effect of Roux-En-Y Gastric Bypass on Plasma Levels of Gastric Biomarkers in Morbidly Obese Women: A Prospective Longitudinal Study. OBES SURG 27, 1901–1905 (2017). https://doi.org/10.1007/s11695-017-2724-4
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DOI: https://doi.org/10.1007/s11695-017-2724-4