Abstract
Background
Despite evidence on gallstone disease after laparoscopic sleeve gastrectomy (LSG), there is an existing lack of consensus on practice guidelines, i.e., surveillance and stone-lowering prophylaxis. Available evidence also has a racial bias as western reports predominate current data. Considering the growing popularity of LSG in Asia and the unique Asian anthropometrics, we have attempted to provide a regional perspective by reviewing our LSG database to investigate the epidemiology of this complication.
Methods
One hundred two morbidly obese cases were retrospectively reviewed. Abdominal ultrasounds were conducted preoperatively and at 12-month post-op. No gallstone-lowering prophylaxis was used. Outcome measure was the incidence of new gallstone formation at 1 year and the rate of symptomatic stones during the follow-up period.
Results
Mean age was 43 years (range 20–68) with average initial BMI of 41.68 kg/m2. Preoperative gallstones were present in 14 (13.7%) cases. At 12-month post-op, 24 (27.5%) patients with no previous gallstone disease developed new stones. Within the mean follow-up period of 28.4 months, only one case (0.9%) developed gallstone complication requiring a cholecystectomy. We found no statistical difference in demographics, BMI variables (initial BMI, ΔBMI at 6 months and 1 year), and comorbidities between patients with new gallstone and those without stones.
Conclusion
Our results match western data in that gallstone formation is common after LSG though incidence of complicated stones is small. This is despite not using gallstone-lowering prophylaxis. The low conversion rate also questions the relevance of surveillance screening, as most patients with new gallstones remain asymptomatic at least in the short-term follow-up.
Similar content being viewed by others
References
Zachariah SK et al. Laparoscopic sleeve gastrectomy for morbid obesity: 5 years experience from an Asian center of excellence. Obes Surg. 2013;23(7):939–46.
Pok EH et al. Laparoscopic sleeve gastrectomy in Asia: long term outcome and revisional surgery. Asian J Surg. 2016;39(1):21–8.
Li VK et al. Symptomatic gallstones after sleeve gastrectomy. Surg Endosc. 2009;23(11):2488–92.
Sioka E, Zacharoulis D, Zachari E, et al, Complicated gallstones after laparoscopic sleeve gastrectomy. J Obes, 2014. 468203
Diehl AK. Epidemiology and natural history of gallstone disease. Gastroenterol Clin N Am. 1991;20(1):1–19.
Shiffman ML et al. Gallstone formation after rapid weight loss: a prospective study in patients undergoing gastric bypass surgery for treatment of morbid obesity. Am J Gastroenterol. 1991;86(8):1000–5.
Shiffman ML et al. Gallbladder mucin, arachidonic acid, and bile lipids in patients who develop gallstones during weight reduction. Gastroenterology. 1993;105(4):1200–8.
Shiffman ML et al. Gallstones in patients with morbid obesity. Relationship to body weight, weight loss and gallbladder bile cholesterol solubility. Int J Obes Relat Metab Disord. 1993;17(3):153–8.
Al-Jiffry BO et al. Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obesity. Can J Gastroenterol. 2003;17(3):169–74.
Deurenberg-Yap M et al. Relationships between indices of obesity and its co-morbidities in multi-ethnic Singapore. Int J Obes Relat Metab Disord. 2001;25(10):1554–62.
Consultation, W.H.O.E. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157–63.
Li VK et al. Predictors of gallstone formation after bariatric surgery: a multivariate analysis of risk factors comparing gastric bypass, gastric banding, and sleeve gastrectomy. Surg Endosc. 2009;23(7):1640–4.
Dhabuwala A, Cannan RJ, Stubbs RS. Improvement in co-morbidities following weight loss from gastric bypass surgery. Obes Surg. 2000;10(5):428–35.
Iglezias Brandao de Oliveira C, Adami Chaim E, da Silva BB. Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obes Surg. 2003;13(4):625–8.
Villegas L et al. Is routine cholecystectomy required during laparoscopic gastric bypass? Obes Surg. 2004;14(2):206–11.
Kiewiet RM et al. Gallstone formation after weight loss following gastric banding in morbidly obese Dutch patients. Obes Surg. 2006;16(5):592–6.
O’Brien PE, Dixon JB. A rational approach to cholelithiasis in bariatric surgery: its application to the laparoscopically placed adjustable gastric band. Arch Surg. 2003;138(8):908–12.
Adams LB et al. Randomized, prospective comparison of ursodeoxycholic acid for the prevention of gallstones after sleeve gastrectomy. Obes Surg. 2016;26(5):990–4.
Tsirline VB et al. How frequently and when do patients undergo cholecystectomy after bariatric surgery? Surg Obes Relat Dis. 2014;10(2):313–21.
Hamad GG et al. Elective cholecystectomy during laparoscopic Roux-en-Y gastric bypass: is it worth the wait? Obes Surg. 2003;13(1):76–81.
Worni M et al. Cholecystectomy concomitant with laparoscopic gastric bypass: a trend analysis of the nationwide inpatient sample from 2001 to 2008. Obes Surg. 2012;22(2):220–9.
Uy MC et al. Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a meta-analysis. Obes Surg. 2008;18(12):1532–8.
Benarroch-Gampel J et al. Cost-effectiveness analysis of cholecystectomy during Roux-en-Y gastric bypass for morbid obesity. Surgery. 2012;152(3):363–75.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The study is not supported by any grants.
Conflict of Interest
The authors declare that they have no conflict of interest.
Formal Consent
For this type of study, formal consent is not required.
Rights and permissions
About this article
Cite this article
Hasan, M.Y., Lomanto, D., Loh, L.L. et al. Gallstone Disease After Laparoscopic Sleeve Gastrectomy in an Asian Population—What Proportion of Gallstones Actually Becomes Symptomatic?. OBES SURG 27, 2419–2423 (2017). https://doi.org/10.1007/s11695-017-2657-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11695-017-2657-y