Impact of Bariatric Surgery on Heme Oxygenase-1, Inflammation, and Insulin Resistance in Morbid Obesity with Obstructive Sleep Apnea

  • Raquel Tirado
  • Maria José Masdeu
  • Laura Vigil
  • Mercedes Rigla
  • Alexis Luna
  • Pere Rebasa
  • Rocío Pareja
  • Marta Hurtado
  • Assumpta Caixàs
Original Contributions

DOI: 10.1007/s11695-017-2635-4

Cite this article as:
Tirado, R., Masdeu, M.J., Vigil, L. et al. OBES SURG (2017). doi:10.1007/s11695-017-2635-4

Abstract

Introduction

Morbid obesity and obstructive sleep apnea (OSA) interact at an inflammatory level. Bariatric surgery reduces inflammatory responses associated with obesity. Heme oxygenase-1 (HO-1) is an enzyme with anti-inflammatory properties, which might be increased in morbid obesity or OSA. We studied morbidly obese patients with OSA to determine: (a) HO-1 plasma concentrations according to OSA severity and their relationship with insulin resistance and inflammation and (b) the impact of bariatric surgery on HO-1 and parameters of insulin resistance and inflammation.

Material and Methods

We analyzed the homeostasis model insulin resistance index (HOMA) and plasma concentrations of HO-1, tumor necrosis factor alpha, interleukin-6, interleukin-1-beta, C reactive protein (CRP), and adiponectin according to polysomnography findings in 66 morbidly obese patients before bariatric surgery and 12 months after surgery.

Results

Before surgery, HO-1 plasma concentrations were similar in three groups of patients with mild, moderate, and severe OSA, and correlated with HOMA (r = 0.27, p = 0.02). Twelve months after surgery, low-grade inflammation and insulin resistance had decreased in all the groups, but HO-1 plasma concentration had decreased only in the severe OSA group (p = 0.02). In this group, the reduction in HO-1 correlated with a reduction in CRP concentrations (r = 0.43, p = 0.04) and with improved HOMA score (r = 0.37, p = 0.03).

Conclusions

Bariatric surgery decreases HO-1 concentrations in morbid obesity with severe OSA, and this decrease is associated with decreases in insulin resistance and in inflammation.

Keywords

Heme oxygenase-1 Bariatric surgery Insulin resistance Inflammation OSA 

Funding information

Funder NameGrant NumberFunding Note
Beques Taulí de Recerca i Innovació, Institut d’Investigació i Innovació Parc Taulí (I3PT)
  • 2014/005

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Endocrinology and Nutrition DepartmentParc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí, Universitat Autònoma de BarcelonaSabadellSpain
  2. 2.Pneumology DepartmentParc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí, Universitat Autònoma de BarcelonaSabadellSpain
  3. 3.Pneumology DepartmentParc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí, Universitat Autònoma de Barcelona, Ciber de Enfermedades Respiratorias-CiberesSabadellSpain
  4. 4.Surgery DepartmentParc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí, Universitat Autònoma de BarcelonaSabadellSpain

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