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Plasma Apelin and Asymmetric Dimethylarginine (ADMA) Levels Shortly After Laparoscopic Greater Curvature Plication

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Abstract

Objectives

We sought to investigate the short-term effect of weight loss following restrictive bariatric surgery on plasma concentrations of apelin and asymmetric dimethylarginine (ADMA) in individuals with morbid obesity.

Subjects/Methods

Thirty-seven morbidly obese individuals underwent laparoscopic greater curvature plication (LGCP). Anthropometric indices and plasma concentrations high-sensitivity C-reactive protein (hsCRP), apelin, and ADMA were measured before and 6 weeks after LGCP.

Results

The percentage of total weight loss was 12.9 ± 4.4% 6 weeks after the operation. ADMA and apelin levels decreased significantly (p < 0.001 and 0.032, respectively) following LGCP. Significant decrements occurred in weight, body mass index, waist and hip circumference (p < 0.001), and waist-to-hip ratio (p = 0.013). The levels of triglycerides (p = 0.017), low-density lipoprotein cholesterol (p = 0.020), fasting plasma glucose (p = 0.033), fasting plasma insulin (p = 0.042), and the homeostasis model assessment index of insulin resistance (p = 0.034) also significantly decreased compared to the baseline measures. No significant change was observed in hsCRP levels and systolic and diastolic blood pressures. There was no significant correlation between changes in levels of apelin or ADMA and changes in anthropometric indices and other laboratory parameters.

Conclusions

Surgically induced weight loss rapidly decreases plasma levels of ADMA and apelin in morbidly obese patients. These changes do not seem correlated with changes in anthropometric and laboratory parameters associated with obesity.

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References

  1. Guh DP, Zhang W, Bansback N, et al. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009;9(1):88.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Esteghamati A, Etemad K, Koohpayehzadeh J, et al. Trends in the prevalence of diabetes and impaired fasting glucose in association with obesity in Iran: 2005–2011. Diabetes Res Clin Pract. 2014;103(2):319–27.

    Article  PubMed  Google Scholar 

  3. Ghoghaei M, Taghdiri F, Khajeh E, et al. Parathyroid hormone levels may predict nonalcoholic steatohepatitis in morbidly obese patients. Hepat Mon. 2015;15(7):e29697.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Van Gaal LF, Mertens IL, Christophe E. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444(7121):875–80.

    Article  CAS  PubMed  Google Scholar 

  5. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 2004;92(03):347–55.

    Article  CAS  PubMed  Google Scholar 

  6. Vallance P, Leone A, Calver A, et al. Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol. 1992;20:S60–S2.

    Article  CAS  PubMed  Google Scholar 

  7. Palomo I, Contreras A, Alarcon LM, et al. Elevated concentration of asymmetric dimethylarginine (ADMA) in individuals with metabolic syndrome. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society. 2011;24(4):224–8.

    Article  CAS  Google Scholar 

  8. Surdacki A, Nowicki M, Sandmann J, et al. Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension. J Cardiovasc Pharmacol. 1999;33(4):652–8.

    Article  CAS  PubMed  Google Scholar 

  9. Boger RH, Bode-Boger SM, Szuba A, et al. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation. 1998;98(18):1842–7.

    Article  CAS  PubMed  Google Scholar 

  10. Abbasi F, Asagmi T, Cooke JP, et al. Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus. Am J Cardiol. 2001;88(10):1201–3.

    Article  CAS  PubMed  Google Scholar 

  11. Vallance P, Leone A, Calver A, et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet. 1992;339(8793):572–5.

    Article  CAS  PubMed  Google Scholar 

  12. Krzyzanowska K, Mittermayer F, Kopp HP, et al. Weight loss reduces circulating asymmetrical dimethylarginine concentrations in morbidly obese women. J Clin Endocrinol Metab. 2004;89(12):6277–81.

    Article  CAS  PubMed  Google Scholar 

  13. Spoto B, Parlongo RM, Parlongo G, et al. The enzymatic machinery for ADMA synthesis and degradation is fully expressed in human adipocytes. Journal of nephrology. 2007;20(5):554.

    PubMed  Google Scholar 

  14. Kimoto M, Whitley GSJ, Tsuji H, et al. Detection of NG, NGdimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody. J Biochem. 1995;117(2):237–8.

    Article  CAS  PubMed  Google Scholar 

  15. Wilcken DE, Sim AS, Wang J, et al. Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of L-arginine on its metabolism. Mol Genet Metab. 2007;91(4):309–17.

    Article  CAS  PubMed  Google Scholar 

  16. Lu TM, Ding YA, Leu HB, et al. Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia. Am J Cardiol. 2004;94(2):157–61.

    Article  CAS  PubMed  Google Scholar 

  17. Mah E, Bruno RS. Postprandial hyperglycemia on vascular endothelial function: mechanisms and consequences. Nutr Res. 2012;32(10):727–40.

    Article  CAS  PubMed  Google Scholar 

  18. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471–6.

    Article  CAS  PubMed  Google Scholar 

  19. Masri B, Knibiehler B, Audigier Y. Apelin signalling: a promising pathway from cloning to pharmacology. Cell Signal. 2005;17(4):415–26.

    Article  CAS  PubMed  Google Scholar 

  20. Boucher J, Masri B, Daviaud D, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology. 2005;146(4):1764–71.

    Article  CAS  PubMed  Google Scholar 

  21. O’Carroll AM, Lolait SJ, Harris LE, et al. The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis. J Endocrinol. 2013;219(1):R13–35.

    Article  PubMed  Google Scholar 

  22. Castan-Laurell I, Dray C, Attane C, et al. Apelin, diabetes, and obesity. Endocrine. 2011;40(1):1–9.

    Article  CAS  PubMed  Google Scholar 

  23. Castan-Laurell I, Boucher J, Dray C, et al. Apelin, a novel adipokine over-produced in obesity: friend or foe? Mol Cell Endocrinol. 2005;245(1–2):7–9.

    Article  CAS  PubMed  Google Scholar 

  24. Bertrand C, Valet P, Castan-Laurell I. Apelin and energy metabolism. Front Physiol. 2015;6:115.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Dray C, Knauf C, Daviaud D, et al. Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab. 2008;8(5):437–45.

    Article  CAS  PubMed  Google Scholar 

  26. Attane C, Foussal C, Le Gonidec S, et al. Apelin treatment increases complete fatty acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes. 2012;61(2):310–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Monteforte MJ, Turkelson CM. Bariatric surgery for morbid obesity. Obes Surg. 2000;10(5):391–401.

    Article  CAS  PubMed  Google Scholar 

  28. Schauer PR, Kashyap SR, Wolski K, et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med. 2012;366(17):1567–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Ghoghaei M, Khajeh E, Taghdiri F, et al. Effects of laparoscopic Roux-en-Y gastric bypass on anthropometric characteristics, hypertension, type 2 diabetes mellitus and metabolic syndrome: an Iranian experience. Galen Medical Journal. 2014;3(3):167–75.

    Google Scholar 

  30. Buchwald H, Oien DM. Metabolic/bariatric surgery worldwide 2008. Obes Surg. 2009;19(12):1605–11.

    Article  PubMed  Google Scholar 

  31. Yermilov I, McGory ML, Shekelle PW, et al. Appropriateness criteria for bariatric surgery: beyond the NIH guidelines. Obesity. 2009;17(8):1521–7.

    Article  PubMed  Google Scholar 

  32. Talebpour M, Amoli BS. Laparoscopic total gastric vertical plication in morbid obesity. Journal of Laparoendoscopic & Advanced Surgical Techniques. 2007;17(6):793–8.

    Article  Google Scholar 

  33. Talebpour M, SMK M, Talebpour A, et al. Twelve year experience of laparoscopic gastric plication in morbid obesity: development of the technique and patient outcomes. Ann Surg Innov Res. 2012;6(1):1.

    Article  Google Scholar 

  34. Deitel M, Greenstein RJ. Recommendations for reporting weight loss. Obes Surg. 2003;13(2):159–60.

    Article  PubMed  Google Scholar 

  35. Schulze F, Wesemann R, Schwedhelm E, et al. Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay. Clinical Chemical Laboratory Medicine. 2004;42(12):1377–83.

    Article  CAS  Google Scholar 

  36. Konukoglu D, Uzun H, Firtina S, et al. Plasma adhesion and inflammation markers: asymmetrical dimethyl-L-arginine and secretory phospholipase A2 concentrations before and after laparoscopic gastric banding in morbidly obese patients. Obes Surg. 2007;17(5):672–8.

    Article  PubMed  Google Scholar 

  37. Krist J, Wieder K, Klöting N, et al. Effects of weight loss and exercise on apelin serum concentrations and adipose tissue expression in human obesity. Obesity facts. 2013;6(1):57–69.

    Article  CAS  PubMed  Google Scholar 

  38. Heinonen MV, Purhonen AK, Miettinen P, et al. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Regul Pept. 2005;130(1–2):7–13.

    Article  CAS  PubMed  Google Scholar 

  39. Heinonen MV, Laaksonen DE, Karhu T, et al. Effect of diet-induced weight loss on plasma apelin and cytokine levels in individuals with the metabolic syndrome. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2009;19(9):626–33.

    Article  CAS  PubMed  Google Scholar 

  40. Caron-Cantin SM, Martin J, Bastien M, et al. Acute and chronic effects of biliopancreatic diversion with duodenal switch surgery on plasma visfatin and apelin levels in patients with severe obesity. Obes Surg. 2013;23(11):1806–14.

    Article  PubMed  Google Scholar 

  41. Soriguer F, Garrido-Sanchez L, Garcia-Serrano S, et al. Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus. Obes Surg. 2009;19(11):1574–80.

    Article  PubMed  Google Scholar 

  42. Zerrweck C, Rodriguez JG, Aramburo E, Vizcarra R, Rodriguez JL, Solorzano A, et al. Revisional surgery following laparoscopic gastric plication. Obes Surg 2016.

  43. Spoto B, Parlongo RM, Parlongo G, et al. The enzymatic machinery for ADMA synthesis and degradation is fully expressed in human adipocytes. J Nephrol. 2007;20(5):554–9.

    PubMed  Google Scholar 

  44. Wozniak SE, Gee LL, Wachtel MS, et al. Adipose tissue: the new endocrine organ? A review article. Dig Dis Sci. 2009;54(9):1847–56.

    Article  PubMed  Google Scholar 

  45. Castan-Laurell I, Vitkova M, Daviaud D, et al. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Eur J Endocrinol. 2008;158(6):905–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Zoccali C, Benedetto FA, Maas R, et al. Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease. J Am Soc Nephrol. 2002;13(2):490–6.

    CAS  PubMed  Google Scholar 

  47. Kadoglou NP, Lampropoulos S, Kapelouzou A, et al. Serum levels of apelin and ghrelin in patients with acute coronary syndromes and established coronary artery disease—KOZANI STUDY. Translational research : the journal of laboratory and clinical medicine. 2010;155(5):238–46.

    Article  CAS  Google Scholar 

  48. El-Shehaby AM, El-Khatib MM, Battah AA, et al. Apelin: a potential link between inflammation and cardiovascular disease in end stage renal disease patients. Scand J Clin Lab Invest. 2010;70(6):421–7.

    Article  CAS  PubMed  Google Scholar 

  49. Mittermayer F, Mayer B, Meyer A, et al. Circulating concentrations of asymmetrical dimethyl-L-arginine are increased in women with previous gestational diabetes. Diabetologia. 2002;45(10):1372–8.

    Article  CAS  PubMed  Google Scholar 

  50. Fard A, Tuck CH, Donis JA, et al. Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes. Arterioscler Thromb Vasc Biol. 2000;20(9):2039–44.

    Article  CAS  PubMed  Google Scholar 

  51. Stühlinger MC, Abbasi F, Chu JW, et al. Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor. JAMA. 2002;287(11):1420–6.

    Article  PubMed  Google Scholar 

  52. Päivä H, Laakso J, Lehtimäki T, et al. Effect of high-dose statin treatment on plasma concentrations of endogenous nitric oxide synthase inhibitors. J Cardiovasc Pharmacol. 2003;41(2):219–22.

    Article  PubMed  Google Scholar 

  53. Eid HM, Eritsland J, Larsen J, et al. Increased levels of asymmetric dimethylarginine in populations at risk for atherosclerotic disease. Effects of pravastatin Atherosclerosis. 2003;166(2):279–84.

    Article  CAS  PubMed  Google Scholar 

  54. Laakso J, Ruokonen I, Rantalaiho V, et al. Plasma concentrations of asymmetric-dimethyl-arginine in type 2 diabetes associate with glycemic control and glomerular filtration rate but not with risk factors of vasculopathy. Metabolism. 2003;52(3):303–7.

    Article  PubMed  Google Scholar 

  55. Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. 2000;23(1):57–63.

    Article  CAS  PubMed  Google Scholar 

  56. Päivä H, Lehtimäki T, Laakso J, et al. Dietary composition as a determinant of plasma asymmetric dimethylarginine in subjects with mild hypercholesterolemia. Metabolism. 2004;53(8):1072–5.

    Article  PubMed  Google Scholar 

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Acknowledgements

This study was funded by the Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences (Grant Number: 20476).

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Authors and Affiliations

  1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Elias Khajeh & Mohsen Afarideh

  2. Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Nekoo Panahi

  3. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Atefeh Golpaie & Mohammad Javad Hosseinzadeh-Attar

  4. School of Medicine, Babol University of Medical Sciences, Babol, Iran

    Sepideh Hosseini Shirvani

  5. Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

    Omid Ghamarnejad

  6. Department of Surgery, Laparoscopic Surgical Ward, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Talebpour

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  1. Elias Khajeh
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  2. Nekoo Panahi
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  3. Atefeh Golpaie
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  4. Sepideh Hosseini Shirvani
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  7. Mohammad Talebpour
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  8. Mohammad Javad Hosseinzadeh-Attar
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Corresponding author

Correspondence to Mohammad Javad Hosseinzadeh-Attar.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All study protocols were conducted in accordance with the principles of the Declaration of Helsinki 1972 and its subsequent revisions and were approved by the ethics committee of the Tehran University of Medical Sciences.

Informed Consent

Written informed consent was obtained from all individual participants included in the study.

Additional information

Elias Khajeh and Nekoo Panahi contributed equally to this work.

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Khajeh, E., Panahi, N., Golpaie, A. et al. Plasma Apelin and Asymmetric Dimethylarginine (ADMA) Levels Shortly After Laparoscopic Greater Curvature Plication. OBES SURG 27, 1596–1603 (2017). https://doi.org/10.1007/s11695-016-2509-1

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  • DOI: https://doi.org/10.1007/s11695-016-2509-1

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