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Different Supplementation Regimes to Treat Perioperative Vitamin B12 Deficiencies in Bariatric Surgery: a Systematic Review


Vitamin B12 dosage in multivitamin supplementation in the current literature is quite variable. There is no consensus about the optimal treatment of vitamin B12 deficiency. A systematic literature search on different supplementation regimes to treat perioperative vitamin B12 deficiencies in bariatric surgery was performed. The methodological quality of ten included studies was rated using the Newcastle Ottawa scale and ranged from moderate to good. The agreement between the reviewers was assessed with a Cohen’s kappa (0.69). The current literature suggests that 350 μg oral vitamin B12 is the appropriate dose to correct low vitamin B12 levels in many patients. Further research must focus on a better diagnosis of a vitamin B12 deficiency, the optimal dose vitamin B12 supplementation, and clinical relevance next to biochemical data.

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Correspondence to H. J. M. Smelt.

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Author 3 reports educational grants from Medtronic and FitForMe. Author 1 and author 2 have nothing to disclose.



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Author Contributions

Study design and data collection: HS, SP

Drafting and revision of the manuscript: HS, SP, JS

Final approval: HS, SP, JS

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Smelt, H., Pouwels, S. & Smulders, J. Different Supplementation Regimes to Treat Perioperative Vitamin B12 Deficiencies in Bariatric Surgery: a Systematic Review. OBES SURG 27, 254–262 (2017).

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  • Bariatric surgery
  • Vitamin B12 supplementation
  • Vitamin B12 deficiency
  • Methylmalonic acid