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Effect of Bariatric Surgery-Induced Weight Loss on Platelet Count and Mean Platelet Volume: a 12-Month Follow-Up Study

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Abstract

Background

Abdominal obesity is strongly correlated with cardiovascular risk and associated with platelet hyperactivity. This hyperactivity is associated with an increase in mean platelet volume (MPV). Few data are available about changes in platelet counts and MPV in obese patients after bariatric surgery (BS). The purpose of this study was to describe quantitative and qualitative changes in the platelet lineage after BS.

Methods

One hundred twenty-eight consecutive patients were included. The mean age was 43 ± 12 years, 77 % of patients were female, and the mean preoperative BMI was 44 ± 6 kg/m2. Ninety patients (71 %) had a Roux-en-Y gastric bypass (RYGBP), and 38 (29 %) had a sleeve gastrectomy (SG). Patients were evaluated preoperatively, and postoperative follow-up was performed at 3, 6, and 12 months. The postoperative evaluation included blood samples for full blood count (FBC), including measure of mean platelet volume (MPV).

Results

At the 12-month follow-up, the reduction in preoperative weight was 29 ± 9 %. We showed a significant decrease in platelet count (245 ± 62 vs. 234 ± 54 G/L; p = 0.0015) found in parallel with a non-significant decrease in MPV (9.27 ± 1.1 vs. 9.22 ± 1.05; p = 0.34). With regard to the intervention type, SG caused a more significant decrease in platelet count than RYGBP (p = 0.02). There was no significant difference in MPV variations between the two groups (p = 0.08).

Conclusions

Our results suggest that BS has a positive impact on platelet metabolism, possibly mediated by weight loss. These data need to be confirmed to understand the multifactorial benefits of BS on cardiovascular risk in obese patients.

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Acknowledgments

The authors thank Dr J. A. Alexandre for biologic data collection.

Author information

Authors and Affiliations

  1. Department of Digestive, Oncologic and Metabolic Surgery, Ambroise Paré Hospital, Boulogne-Billancourt, France

    Loïc Raoux, David Moszkowicz, Karina Vychnevskaia, Tigran Poghosyan & Jean-Luc Bouillot

  2. Service de Chirurgie Digestive, Oncologique et Métabolique, Hôpital Ambroise Paré, 9 avenue Charles de Gaulle, 92100, Boulogne-Billancourt, France

    David Moszkowicz

  3. Versailles St-Quentin-en-Yvelines University, 78180, Montigny-Le-Bretonneux, France

    David Moszkowicz, Tigran Poghosyan, Sylvain Clauser, Marion Bretault, Sébastien Czernichow & Jean-Luc Bouillot

  4. Department of Biostatistics, Ambroise Paré Hospital, Boulogne-Billancourt, France

    Alain Beauchet

  5. Department of Hematology, Ambroise Paré Hospital, Boulogne-Billancourt, France

    Sylvain Clauser

  6. Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt, France

    Marion Bretault, Sébastien Czernichow & Claire Carette

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  1. Loïc Raoux
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  2. David Moszkowicz
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  10. Jean-Luc Bouillot
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Corresponding author

Correspondence to David Moszkowicz.

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Ethical Approval Statement

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Conflict of Interest

The authors declare that they have no conflicts of interest.

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Raoux, L., Moszkowicz, D., Vychnevskaia, K. et al. Effect of Bariatric Surgery-Induced Weight Loss on Platelet Count and Mean Platelet Volume: a 12-Month Follow-Up Study. OBES SURG 27, 387–393 (2017). https://doi.org/10.1007/s11695-016-2292-z

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  • DOI: https://doi.org/10.1007/s11695-016-2292-z

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