We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.
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The project was supported by the National Center for Research Resources (NCRR) and the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) through Grant Number KL2 RR025740 and KL2 TR000107. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work was also supported by funding from the Northwestern Memorial Foundation Dixon Translational Research Grants. Genotyping services were provided by the Northwestern Genomics Core.
Conflict of Interest
Laura J. Rasmussen-Torvik, no conflict of interest.
Abigail S. Baldridge, no conflict of interest.
Jennifer A. Pacheco, no conflict of interest.
Sharon A Aufox, no conflict of interest.
Kwang-Youn A. Kim, no conflict of interest.
Jonathan C Silverstein, no conflict of interest.
Erwin W Denham, no conflict of interest.
Eric Hungness, no conflict of interest.
Maureen E Smith, no conflict of interest.
Philip Greenland, no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research board and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Rasmussen-Torvik, L.J., Baldridge, A.S., Pacheco, J.A. et al. rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery. OBES SURG 25, 2225–2229 (2015). https://doi.org/10.1007/s11695-015-1872-7
- Bariatric surgery
- Repeated measures
- Long-term weight loss
- Roux-en-Y gastric bypass
- Obesity GWAS