Abstract
Introduction
Malabsorptive bariatric procedures, like the biliopancreatic diversion (BPD) and BPD with duodenal switch (BPD/DS), have excellent results in terms of weight loss. However, these malabsorptive techniques are associated with severe malnutrition and vitamin deficiencies. The aim of this study was to evaluate the vitamin and mineral status after BPD and BPD/DS in the long term.
Methods
All patients who underwent BPD or BPD/DS were selected and invited for an additional follow-up (FU) visit, including blood sampling for vitamin and mineral levels.
Results
Forty patients completed the blood sampling with a median FU of 42 (range 12–90) months. At that time, all patients used some kind of supplementation. However, 93 % of all patients were diagnosed with a deficiency. There were no significant differences in mean serum level vitamins and minerals between BPD and BPD/DS. Forty-three per cent of the patients were anaemic, and 40 % had an iron deficiency (ID). High deficiency rates for fat-soluble vitamins were present: vitamin A in 28 %, vitamin D in 60 %, vitamin E in 10 % and vitamin K in 60 % of the patients. Hypervitaminosis was found in 43 % of the patients for vitamin B1 and in 50 % for vitamin B6.
Conclusion
High numbers of vitamin and mineral deficiencies were found after BPD and BPD/DS despite vitamin supplementation. Anaemia, ID and deficiencies for fat-soluble vitamins are frequently diagnosed. Repeated monitoring is necessary to detect deficiencies at an early stage. Taking all of this into consideration, a stringent multivitamin supplementation regimen should be implemented after malabsorptive procedures.
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References
Buchwald H, Oien DM. Metabolic/bariatric surgery worldwide 2011. Obes Surg. 2013;23(4):427–36.
Scopinaro N, Gianetta E, Pandolfo N, Anfossi A, Berretti B, Bachi V. Bilio-pancreatic bypass proposal and preliminary experimental study of a new type of operation for the functional surgical treatment of obesity. Minerva Chir. 1976;31(10):560–6.
Scopinaro N, Adami GF, Marinari GM, Gianetta E, Traverso E, Friedman D, et al. Biliopancreatic diversion. World J Surg. 1998;22(9):936–46.
\Dolan K, Hatzifotis M, Newbury L, Lowe N, Fielding G. A clinical and nutritional comparison of biliopancreatic diversion with and without duodenal switch. Ann Surg. 2004;240(1):51–6.
Iannelli A, Schneck AS, Topart P, Carles M, Hebuterne X, Gugenheim J. Laparoscopic sleeve gastrectomy followed by duodenal switch in selected patients versus single-stage duodenal switch for superobesity: case–control study. Surg Obes Relat Dis. 2013;9(4):531–8.
de Luis DA, Pacheco D, Izaola O, Terroba MC, Cuellar L, Martin T. Clinical results and nutritional consequences of biliopancreatic diversion: three years of follow-up. Ann Nutr Metab. 2008;53(3–4):234–9.
de Luis DA, Pacheco D, Izaola O, Terroba MC, Cuellar L, Martin T. Zinc and copper serum levels of morbidly obese patients before and after biliopancreatic diversion: 4 years of follow-up. J Gastrointest Surg. 2011;15(12):2178–81.
Astiarraga B, Gastaldelli A, Muscelli E, Baldi S, Camastra S, Mari A, et al. Biliopancreatic diversion in nonobese patients with type 2 diabetes: impact and mechanisms. J Clin Endocrinol Metab. 2013;98(7):2765–73.
Scopinaro N, Adami GF, Papadia FS, Camerini G, Carlini F, Briatore L, et al. The effects of biliopancreatic diversion on type 2 diabetes mellitus in patients with mild obesity (BMI 30–35 kg/m2) and simple overweight (BMI 25–30 kg/m2): a prospective controlled study. Obes Surg. 2011;21(7):880–8.
Marceau P, Biron S, Hould FS, Lebel S, Marceau S, Lescelleur O, et al. Duodenal switch: long-term results. Obes Surg. 2007;17(11):1421–30.
Dapri G, Cadiere GB, Himpens J. Superobese and super-superobese patients: 2-step laparoscopic duodenal switch. Surg Obes Relat Dis. 2011;7(6):703–8.
Baltasar A, Bou R, Miro J, Bengochea M, Serra C, Perez N. Laparoscopic biliopancreatic diversion with duodenal switch: technique and initial experience. Obes Surg. 2002;12(2):245–8.
Hess DS, Hess DW. Biliopancreatic diversion with a duodenal switch. Obes Surg. 1998;8(3):267–82.
EO Aarts, P Koehestani, K Dogan, FJ Berends, ICM Janssen. Revisional surgery after failed gastric banding: results of one-stage conversion to RYGB in 195 patients. Surg Obes Relat Dis. 2014 July 14, 2014. Epub Published online. http://dx.doi.org/10.1016/j.soard.2014.07.006.
Marceau P, Biron S, Hould FS, Lebel S, Marceau S, Lescelleur O, et al. Duodenal switch improved standard biliopancreatic diversion: a retrospective study. Surg Obes Relat Dis. 2009;5(1):43–7.
Rhode BM, Shustik C, Christou NV, MacLean LD. Iron absorption and therapy after gastric bypass. Obes Surg. 1999;9(1):17–21.
Brolin RE, Gorman JH, Gorman RC, Petschenik AJ, Bradley LJ, Kenler HA, et al. Are vitamin B12 and folate deficiency clinically important after Roux-en-Y gastric bypass? J Gastrointest Surg. 1998;2(5):436–42.
Laurenius A, Taha O, Maleckas A, Lonroth H, Olbers T. Laparoscopic biliopancreatic diversion/duodenal switch or laparoscopic Roux-en-Y gastric bypass for super-obesity-weight loss versus side effects. Surg Obes Relat Dis. 2010;6(4):408–14.
Schweitzer DH. Mineral metabolism and bone disease after bariatric surgery and ways to optimize bone health. Obes Surg. 2007;17(11):1510–6.
Brzozowska MM, Sainsbury A, Eisman JA, Baldock PA, Center JR. Bariatric surgery, bone loss, obesity and possible mechanisms. Obes Rev. 2013;14(1):52–67.
Balsa JA, Botella-Carretero JI, Gomez-Martin JM, Peromingo R, Arrieta F, Santiuste C, et al. Copper and zinc serum levels after derivative bariatric surgery: differences between Roux-en-Y gastric bypass and biliopancreatic diversion. Obes Surg. 2011;21(6):744–50.
Cominetti C, Garrido Jr AB, Cozzolino SM. Zinc nutritional status of morbidly obese patients before and after Roux-en-Y gastric bypass: a preliminary report. Obes Surg. 2006;16(4):448–53.
Juel J, Pareek M, Langfrits CS, Jensen SE. Anaphylactic shock and cardiac arrest caused by thiamine infusion. BMJ Case Rep. 2013;2013.
Snodgrass SR. Vitamin neurotoxicity. Mol Neurobiol. 1992;6(1):41–73.
Aarts EO, Janssen IM, Berends FJ. The gastric sleeve: losing weight as fast as micronutrients? Obes Surg. 2011;21(2):207–11.
Curro G, Centorrino T, Cogliandolo A, Dattola A, Pagano G, Barbera A, et al. A clinical and nutritional comparison of biliopancreatic diversion performed with different common and alimentary channel lengths. Obes Surg. 2014 Jun 26.
Guedea ME, del Amo AD, Solanas JA, Marco CA, Bernado AJ, Rodrigo MA, et al. Results of biliopancreatic diversion after five years. Obes Surg. 2004;14(6):766–72.
Conflict of Interest
J. Homan, B. Betzel, E.O. Aarts, K. Dogan, C.J.H.M. van Laarhoven, I.M.C. Janssen and F.J. Berends have no conflict of interests to declare.
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Homan, J., Betzel, B., Aarts, E.O. et al. Vitamin and Mineral Deficiencies After Biliopancreatic Diversion and Biliopancreatic Diversion with Duodenal Switch—the Rule Rather than the Exception. OBES SURG 25, 1626–1632 (2015). https://doi.org/10.1007/s11695-015-1570-5
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DOI: https://doi.org/10.1007/s11695-015-1570-5