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Laparoscopic Sleeve Gastrectomy Versus Laparoscopic Roux-En-Y Gastric Bypass for Morbid Obesity and Related Comorbidities: A Meta-Analysis of 21 Studies

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An Erratum to this article was published on 07 October 2014

Abstract

Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) are two most common weight loss procedures; our meta-analysis aims to compare these two in the treatment of morbid obesity and its related comorbidities. An electronic literature research of published studies concerning LRYGB and LSG was performed from inception to October 2013. Percentage of excess weight loss (%EWL), resolution or improvement rate of comorbidities, and adverse events were all pooled and compared by the software Review Manager 5.1. As a result, a total of 21 studies involving 18,766 morbidly obese patients were eventually selected according to the inclusion criteria. No significant difference was found in %EWL during 0.5- to 1.5-year follow-up (P > 0.05), but after that, LRYGB achieved higher %EWL than LSG (P < 0.05). Except for type 2 diabetes mellitus (T2DM) (P < 0.001), the difference between these two procedures in the resolution or improvement rate of other comorbidities did not reach a statistical significance (P > 0.05). There were more adverse events in LRYGB compared with LSG (P < 0.01). In conclusion, LRYGB is superior to LSG in efficacy but inferior to LSG in safety.

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Conflict of Interest

The authors declare that they have no conflict of interest with the materials presented here.

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, Inner Mongolia People’s Hospital, No. 20 Zhao Wuda Road, Hohhot, Inner Mongolia, 010017, China

    Yong Zhang & Wang Ju

  2. Department of Minimally Invasive Centre, Nankai Hospital of Tianjin Medical University, No. 122 San Wei Road, Nankai district, Tianjin, 300100, China

    Yong Zhang, Wang Ju, Xiangyu Sun, Zhanguo Cao, Xu Xinsheng, Liu Daquan & Mingfang Qin

  3. Inner Mongolia Baogang Hospital, No. 20, Shao Xian Road, Kundulun district, Baotou, Inner Mongolia, China

    Xin Xiangyang

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  1. Yong Zhang
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Correspondence to Mingfang Qin.

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Zhang, Y., Ju, W., Sun, X. et al. Laparoscopic Sleeve Gastrectomy Versus Laparoscopic Roux-En-Y Gastric Bypass for Morbid Obesity and Related Comorbidities: A Meta-Analysis of 21 Studies. OBES SURG 25, 19–26 (2015). https://doi.org/10.1007/s11695-014-1385-9

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