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The Acute Effects of a New Type of Implantable Gastric Electrical Stimulators Featuring Varied Pulse Widths on Beagle Dogs’ Food Intake and Gastric Accommodation

Obesity Surgery volume 24, pages 783–790 (2014)Cite this article

Abstract

Background

To improve the therapeutic effects of gastric electrical stimulation (GES) for obesity, an animal experiment was conducted using a new type of stimulators. Proper parameters of GES were selected, and the impacts of GES on the food intake and gastric accommodation of canines were observed.

Methods

Eight beagle dogs were operated on, and GES was performed on them. Firstly, GES was performed to determine the right parameters according to symptoms. Secondly, the so selected parameters were used in a 3-day GES procedure, during which process food intake, body weight, and symptoms were recorded. Thirdly, the gastric capacities before and after GES with different pulse widths were measured by means of a barostat.

Results

The selected parameters varied for each dog, with the pulse widths ranging from 0.3 to 6 ms. The food consumption after GES dropped significantly as compared with the amount observed in the sham stimulation. Tolerance to stimulation could be observed during GES. The post-GES gastric fundus capacity increased evidently in comparison with the capacity before GES, suggesting significant distention as compared with sham stimulation. Given an increment of 2 ms in the pulse width twice, the gastric capacity continued to distend each time.

Conclusions

GES featuring pulse trains with wider and individualized pulse widths could inhibit food consumption of dogs. The stimulation parameters should be selected individually and adjusted periodically. GES of this mode could also increase the fasting gastric capacity with certain dose-related effects. The new type of stimulators may be more suitable for the treatment of human obesity than traditional stimulators.

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References

  1. Park MI, Camilleri M. Gastric motor and sensory functions in obesity. Obes Res. 2005;13(3):491–500.

    PubMed  Article  Google Scholar 

  2. Hargrave SL, Kinzig KP. Repeated gastric distension alters food intake and neuroendocrine profiles in rats. Physiol Behav. 2012;105(4):975–81.

    PubMed Central  PubMed  Article  CAS  Google Scholar 

  3. Messina G, De Luca V, Viggiano A, et al. Autonomic nervous system in the control of energy balance and body weight: personal contributions. Neurol Res Int. Epub 2013 Apr 11.

  4. Mejía-Rivas M, Remes-Troche J, Montaño-Loza A, et al. Gastric capacity is related to body mass index in obese patients. A study using the water load test. Rev Gastroenterol Mex. 2009;74(1):71–3.

    PubMed  Google Scholar 

  5. Hellström PM. Satiety signals and obesity. Curr Opin Gastroenterol. 2013;29(2):222–7.

    PubMed  Article  CAS  Google Scholar 

  6. Abell TL, Minocha A, Abidi N. Looking to the future: electrical stimulation for obesity. Am J Med Sci. 2006;331(4):226–32.

    PubMed  Article  Google Scholar 

  7. Xing JH, Chen JD. Effects and mechanisms of long-pulse gastric electrical stimulation on canine gastric tone and accommodation. Neurogastroenterol Motil. 2006;18(2):136–43.

    PubMed  Article  CAS  Google Scholar 

  8. Qin C, Chen JD, Zhang J, et al. Modulatory effects and afferent pathways of gastric electrical stimulation on rat thoracic spinal neurons receiving input from the stomach. Neurosci Res. 2007;57(1):29–39.

    PubMed Central  PubMed  Article  Google Scholar 

  9. Zhang J, Maude-Griffin R, Zhu H, et al. Gastric electrical stimulation parameter dependently alters ventral medial hypothalamic activity and feeding in obese rats. Am J Physiol Gastrointest Liver Physiol. 2011;301(5):G912–8.

    PubMed  Article  CAS  Google Scholar 

  10. Yao SK, Ke MY, Wang ZF, et al. Visceral response to acute retrograde gastric electrical stimulation in healthy human. World J Gastroenterol. 2005;11(29):4541–6.

    PubMed  Google Scholar 

  11. Yao S, Ke MY, Wang Z, et al. Retrograde gastric pacing reduces food intake and delays gastric emptying in humans: a potential therapy for obesity? Dig Dis Sci. 2005;50(9):1569–75.

    PubMed  Article  Google Scholar 

  12. Ouyang H, Xing J, Chen J. Electroacupuncture restores impaired gastric accommodation in vagotomized dogs. Dig Dis Sci. 2004;49(9):1418–24.

    PubMed  Article  Google Scholar 

  13. Meulemans AL, Eelen JG, Schuurkes JA. NO mediates gastric relaxation after brief vagal stimulation in anesthetized dogs. Am J Physiol. 1995;269(2 Pt 1):G255–61.

    PubMed  CAS  Google Scholar 

  14. Xiaojuan Guo, Yanmei Li, Shukun Yao, et al. Parameter selection and stimulating effects of an adjustable gastric electrical stimulator in dogs. Obes Surg. 2013;19, Epub ahead of print.

  15. Cigaina V. Gastric pacing as therapy for morbid obesity: preliminary results. Obes Surg. 2002;12(3):421.

    Article  Google Scholar 

  16. Chen JZ, Ueno T, Xu X, et al. Reverse gastric pacing reduces food intake without inducing symptoms in dogs. Scand J Gastroenterol. 2006;41(1):30–6.

    PubMed  Article  Google Scholar 

  17. Xing JH, Brody F, Brodsky J, et al. Gastric electrical-stimulation effects on canine gastric emptying, food intake, and body weight. Obes Res. 2003;11(1):41–7.

    PubMed  Article  Google Scholar 

  18. Cigaina V, Saggioro A, Rigo V, et al. Long-term effects of gastric pacing to reduce feed intake in swine. Obes Surg. 1996;6(3):250–3.

    PubMed  Article  Google Scholar 

  19. Chen J, Koothan T, Chen JD. Synchronized gastric electrical stimulation improves vagotomy-induced impairment in gastric accommodation via the nitrergic pathway in dogs. Am J Physiol Gastrointest Liver Physiol. 2009;296(2):G310–8.

    PubMed Central  PubMed  Article  CAS  Google Scholar 

  20. Lei Y, Xing J, Chen JD. Effects and mechanisms of implantable gastric stimulation on gastric distention in conscious dogs. Obes Surg. 2005;15(4):528–33.

    PubMed  Article  Google Scholar 

  21. Xu X, Lei Y, Chen JD. Effects and mechanisms of electrical stimulation of the stomach, duodenum, ileum, and colon on gastric tone in dogs. Dig Dis Sci. 2010;55(4):895–901.

    PubMed  Article  Google Scholar 

  22. Ouyang H, Yin J, Chen JD. Gastric or intestinal electrical stimulation-induced increase in gastric volume is correlated with reduced food intake. Scand J Gastroenterol. 2006;41(11):1261–6.

    PubMed  Article  Google Scholar 

  23. Wang GJ, Tomasi D, Backus W, et al. Gastric distention activates satiety circuitry in the human brain. Neuroimage. 2008;39(4):1824–31.

    PubMed  Article  Google Scholar 

  24. Spyropoulos C, Katsakoulis E, Mead N, et al. Intragastric balloon for high-risk super-obese patients: a prospective analysis of efficacy. Surg Obes Relat Dis. 2007;3(1):78–83.

    PubMed  Article  Google Scholar 

  25. Sun Y, Chen JD. Gastric electrical stimulation reduces gastric tone energy dependently. Scand J Gastroenterol. 2005;40(2):154–9.

    PubMed  Article  CAS  Google Scholar 

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (grant no. 81070299), the Capital Medical Development Foundation of China (grant no. 2009–2018), and the National High Technology Research and Development Program of China (grant no. 2012AA021104).

Conflict of interest

We (Yanmei Li, Shukun Yao, Shaoxuan Chen, Xiaojuan Guo, Yanli Zhang, Wenjuan Zhang, and Weishuo Zhang) declare that we have no conflict of interest with any other people or organizations that can inappropriately influence our work.

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Affiliations

  1. Department of Gastroenterology, China-Japan Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing, 100029, China

    Yanmei Li, Shukun Yao, Shaoxuan Chen, Yanli Zhang, Xiaojuan Guo, Weishuo Zhang & Wenjuan Guo

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  1. Yanmei Li
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  2. Shukun Yao
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  3. Shaoxuan Chen
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  4. Yanli Zhang
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  5. Xiaojuan Guo
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  6. Weishuo Zhang
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  7. Wenjuan Guo
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Corresponding author

Correspondence to Shukun Yao.

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Li, Y., Yao, S., Chen, S. et al. The Acute Effects of a New Type of Implantable Gastric Electrical Stimulators Featuring Varied Pulse Widths on Beagle Dogs’ Food Intake and Gastric Accommodation. OBES SURG 24, 783–790 (2014). https://doi.org/10.1007/s11695-013-1158-x

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  • DOI: https://doi.org/10.1007/s11695-013-1158-x

Keywords

  • Gastric electrical stimulation
  • Parameters
  • Gastric capacity
  • Obesity
  • Canine