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The Effect of Laparoscopic Gastric Bypass on Dyslipidemia in Severely Obese Patients: a 5-Year Follow-up Analysis

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Abstract

Background

Dyslipidemia is common in the morbidly obese population. A previous study from our institution demonstrated improved lipid parameters 1 and 2 years after laparoscopic Roux-en-Y gastric bypass (LRYGB) with fewer patients taking lipid-modifying medications postoperatively, suggesting cost-savings over time. Our objective was to evaluate lipid parameters and lipid-modifying medication use at 5 years postoperative.

Methods

The medical records of patients who underwent LRYGB from September 2001 through July 2008 were reviewed. Inclusion criteria consisted of both preoperative and 5-year postoperative lipid values available.

Results

Six hundred eighty-two patients underwent LRYGB during the study period; 450 had data available at 5 years postoperative, and 187 patients met the inclusion criteria. Mean age was 46.3 years, and 83 % were women. Mean preoperative body mass index was 47.4 kg/m2. Total cholesterol was 191.2 ± 35.4 preoperatively and 181.1 ± 33.0 at 5 years postoperative (P = 0.003). Low-density lipoprotein (LDL) was 107.9 ± 30.9 preoperatively and 95.3 ± 29.7 at 5 years postoperative (P < 0.001). High-density lipoprotein (HDL) was 48.7 ± 12.8 preoperatively and 65.1 ± 18.0 at 5 years postoperative (P < 0.001). Triglycerides were 171.3 ± 78.6 preoperatively and 112.9 ± 60.7 5 years postoperative (P < 0.001). Preoperatively, 35 % of patients were on lipid-modifying medications, and at 5 years postoperatively, 26 % required lipid-modifying medications (P = 0.002).

Conclusions

Patients who have undergone LRYGB continue to show favorable change in their lipid profiles at 5 years postoperative. Furthermore, fewer patients were taking lipid-modifying medications at 5 years postoperatively than preoperatively.

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Conflict of Interest

None of the authors have conflict of interest to disclose.

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Authors and Affiliations

  1. General Surgery Residency, Department of Medical Education, Gundersen Medical Foundation, La Crosse, WI, USA

    Jill S. Ties

  2. Department of Internal Medicine, Gundersen Health System, La Crosse, WI, USA

    Jonathan A. Zlabek

  3. Department of Research, Gundersen Medical Foundation, La Crosse, WI, USA

    Kara J. Kallies & Mohammed Al-Hamadini

  4. Department of General and Vascular Surgery, Gundersen Health System, 1900 South Avenue, C05-001, La Crosse, WI, 54601, USA

    Shanu N. Kothari

Authors
  1. Jill S. Ties
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  2. Jonathan A. Zlabek
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  3. Kara J. Kallies
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  4. Mohammed Al-Hamadini
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  5. Shanu N. Kothari
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Correspondence to Shanu N. Kothari.

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Ties, J.S., Zlabek, J.A., Kallies, K.J. et al. The Effect of Laparoscopic Gastric Bypass on Dyslipidemia in Severely Obese Patients: a 5-Year Follow-up Analysis. OBES SURG 24, 549–553 (2014). https://doi.org/10.1007/s11695-013-1120-y

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  • DOI: https://doi.org/10.1007/s11695-013-1120-y

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