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Obesity Surgery

, Volume 23, Issue 12, pp 2042–2049 | Cite as

Maternal Ileal Interposition Surgery Confers Metabolic Improvements to Offspring Independent of Effects on Maternal Body Weight in UCD-T2DM Rats

  • Bethany P. CummingsEmail author
  • James L. Graham
  • Kimber L. Stanhope
  • Michael L. Chouinard
  • Peter J. Havel
Original Contributions

Abstract

Background

Increasing numbers of people are undergoing bariatric surgery, of which approximately half are women in their childbearing years. However, information on the long-term effects of maternal bariatric surgery in their children is lacking. Furthermore, since bariatric surgery is performed to reduce body weight, clinical studies have not been able to differentiate between benefits to the child due to maternal body weight loss versus other maternal postoperative metabolic changes. Therefore, we used the University of California, Davis, type 2 diabetes mellitus (UCD-T2DM) rat model to test the hypothesis that maternal ileal interposition (IT) surgery would confer beneficial metabolic effects in offspring, independent of effects on maternal body weight.

Methods

IT surgery was performed on 2-month-old prediabetic female UCD-T2DM rats. Females were bred 3 weeks after surgery, and male pups were studied longitudinally.

Results

Maternal IT surgery resulted in decreased body weight in offspring compared with sham offspring (P < 0.05). IT offspring exhibited improvements of glucose-stimulated insulin secretion and nutrient-stimulated glucagon-like peptide-2 (GLP-2) secretion (P < 0.05). Fasting plasma unconjugated bile acid concentrations were 4-fold lower in IT offspring compared with sham offspring at two months of age (P < 0.001).

Conclusions

Overall, maternal IT surgery confers modest improvements of body weight and improves insulin secretion and nutrient-stimulated GLP-2 secretion in offspring in the UCD-T2DM rat model of type 2 diabetes, indicating that this is a useful model for investigating the weight-independent metabolic effects of maternal bariatric surgery.

Keywords

Ileal interposition Maternal effects Glucagon-like peptide-1 

Notes

Acknowledgments

We thank Ruby Hsieh, Susan Bennett, Cheryl Phillips, and the Meyer Hall Animal Facility for their excellent animal care. We thank Linda Jung and MSD for the use of the Sector Imager 240. We thank Philip Sipes for technical support with the bile acid analyses. This research was supported NIH grant 1RC1DK087307-01 and the University of California, Davis Veterinary Scientist Training Program. Dr. Havel’s laboratory also received funding during the project period from NIH grants AT-002993, AT-003545, HL-075675, HL-091333, DK-095980, and R01-HL-107256 and a Multicampus Award from the University of California, Office of the President. This research was also partly supported by NIH grant R01DK095960 to B.P.C. and P.J.H.

Conflict of Interest

All authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Bethany P. Cummings
    • 1
    • 3
    Email author
  • James L. Graham
    • 2
    • 3
  • Kimber L. Stanhope
    • 2
    • 3
  • Michael L. Chouinard
    • 4
  • Peter J. Havel
    • 2
    • 3
  1. 1.Department of Biomedical SciencesCollege of Veterinary MedicineIthacaUSA
  2. 2.Department of Molecular Biosciences, School of Veterinary MedicineUniversity of California, DavisDavisUSA
  3. 3.Department of NutritionUniversity of California, DavisDavisUSA
  4. 4.Lilly Research Laboratories, Lilly Corporate CenterEli Lilly and CompanyIndianapolisUSA

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