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Nitric Oxide, Oxidant Status and Antioxidant Response in Morbidly Obese Patients: the Impact of 1-Year Surgical Weight Loss

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Abstract

Background

The aims of this study were to evaluate nitric oxide (NO) metabolites (nitrite/nitrate NO x ) as proinflammatory parameter and total oxidant status (TOS) as well as total antioxidant response (TAR) as oxidative stress (OS) markers in morbidly obese (MO) patients in comparison with normal-weight healthy (NWH) subjects and to determine the post-bariatric surgery changes of NO x and OS indicators in relation with weight loss.

Methods

We examined serum NO x , TOS, and TAR in a bariatric group of MO patients and a NWH control group (n = 23 each group). In the NWH group, serum was examined once, while in the MO group, serum was examined before and at 3, 6, and 12 months after silastic ring vertical gastroplasty (SRVG).

Results

Serum NO x and TOS values were higher (p < 0.001), while TAR level was lower (p < 0.001) in MO patients as compared to the NWH group. No significant changes occurred at 12 months after surgery in the MO group as far as the NO x (p = 0.93), TOS (p = 0.11), and TAR (p = 0.15) levels were concerned as compared to baseline values. However, NO x increased at 6 months after surgery (p < 0.008) and then decreased by the 12th month after SRVG (p < 0.008), reaching almost baseline values.

Conclusions

At baseline, there was a high production of proinflammatory and OS markers in MO patients. SRVG surgical weight loss was not accompanied by significant changes of these parameters at 1 year after surgery.

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Acknowledgments

This work was supported by the research grant from the National Council for Scientific Research in Romanian Higher Education CNCSIS TD code 409 (80/1.10.2007). This study has been presented at the 16th World Congress of IFSO, Hamburg, Germany, Sept. 1–3, 2011. The authors express their great gratitude to Professor Mervyn Deitel, MD, and to Anna Maria Wolf, MD, for their suggestions on the manuscript.

Conflict of Interest

All authors, Adriana Florinela Cătoi, Alina Pârvu, Romeo Florin Galea, Ioana Delia Pop, Adriana Mureşan, and Cornel Cătoi, declare that they have no conflict of interests to disclose.

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Authors and Affiliations

  1. Department of Functional Sciences, Medicine Faculty, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş 8, 400012, Cluj-Napoca, Romania

    Adriana Florinela Cătoi, Alina Pârvu & Adriana Mureşan

  2. Second Surgical Clinic, Medicine Faculty, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş 8, 400012, Cluj-Napoca, Romania

    Romeo Florin Galea

  3. Department of Exact Sciences, Horticulture Faculty, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Mănăştur, 400372, Cluj-Napoca, Romania

    Ioana Delia Pop

  4. Department of Pathology, Veterinary Medicine Faculty, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Mănăştur, 400372, Cluj-Napoca, Romania

    Cornel Cătoi

Authors
  1. Adriana Florinela Cătoi
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  2. Alina Pârvu
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  3. Romeo Florin Galea
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  4. Ioana Delia Pop
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  6. Cornel Cătoi
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Correspondence to Alina Pârvu.

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Cătoi, A.F., Pârvu, A., Galea, R.F. et al. Nitric Oxide, Oxidant Status and Antioxidant Response in Morbidly Obese Patients: the Impact of 1-Year Surgical Weight Loss. OBES SURG 23, 1858–1863 (2013). https://doi.org/10.1007/s11695-013-0968-1

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