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Obesity Surgery

, Volume 23, Issue 5, pp 650–656 | Cite as

Overweight Patients Achieve Ideal Body Weight Following Curative Gastrectomy Resulting in Better Long-Term Prognosis

  • Fanming Kong
  • Hui Li
  • Yongli Fan
  • Xinwei Zhang
  • Shui Cao
  • JinPu Yu
  • Xiubao RenEmail author
  • Xishan HaoEmail author
Original Contributions

Abstract

Background

The relationship between body mass index (BMI) and long-term outcome in gastric cancer patients following radical gastrectomy continues to be debated. We investigated the association between BMI, clinicopathological features, and prognosis in Chinese gastric carcinoma patients.

Methods

A retrospective consecutive cohort study was performed on 1,296 patients who underwent gastrectomy with curative intent at the Tianjin Cancer Institute Hospital between 1999 and 2004. The clinicopathological characteristics, overall 5-year survival rate (OS), and preoperative and six-month postoperative BMIs of both overweight (BMI ≥25 kg/m2; H-BMI; n = 364) and non-overweight (BMI <25 kg/m2; N-BMI; n = 932) patients were compared.

Results

Among these patients, 364 (28.1 %) were overweight. The OS was significantly higher in the H-BMI than N-BMI group (33.2 vs. 24.1 %, respectively; p < 0.001). Preoperative and six-month postoperative BMIs were 27.1 ± 2.0 and 24.8 ± 2.0 kg/m2, respectively, in the H-BMI group (p < 0.001), whereas they were 21.7 ± 2.2 and 20.7 ± 2.2 kg/m2, respectively, in the N-BMI group (p = 0.007). There was significantly better differentiation (p = 0.034), less distant metastases (p = 0.006), and a lower metastatic lymph node ratio (p = 0.014) observed in the H-BMI groups. Multivariate analyses indicated age, BMI, pathological tumor depth, distant metastases, metastatic lymph node ratio, and tumor size as independent prognostic factors.

Conclusions

Our findings suggest that overweight patients were less likely to have tumors with aggressive features and can achieve ideal body weight following curative gastrectomy, possibly resulting in better long-term prognosis

Keywords

Gastric carcinoma Curative gastrectomy Prognostic factors Body mass index 

Notes

Acknowledgments

We thank Debra Liu for critical reading of the manuscript. This work is supported by the Natural Science Foundation of China (no. 30901754 and no. 30901376) and Innovation Funding for Graduates of Tianjin Medical University, third Phase of the 211 Project for Higher Education (no. 2010GSI01).

Conflict of Interest

All authors have no potential conflicts of interest.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Fanming Kong
    • 1
    • 2
  • Hui Li
    • 2
  • Yongli Fan
    • 1
    • 2
  • Xinwei Zhang
    • 1
  • Shui Cao
    • 1
  • JinPu Yu
    • 2
  • Xiubao Ren
    • 1
    • 2
    Email author
  • Xishan Hao
    • 1
    • 2
    Email author
  1. 1.Department of BiotherapyTianjin Medical University Cancer Institute and HospitalTianjinChina
  2. 2.Key Laboratory of Cancer Prevention and TherapyTianjin Medical University Cancer Institute and HospitalTianjinChina

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