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Obesity Surgery

, Volume 20, Issue 6, pp 744–748 | Cite as

Alcohol Absorption Modification After a Laparoscopic Sleeve Gastrectomy Due to Obesity

  • Fernando MaluendaEmail author
  • Attila Csendes
  • Xabier De Aretxabala
  • Jaime Poniachik
  • Karen Salvo
  • Iris Delgado
  • Patricia Rodriguez
Clinical Report

Abstract

Background

The different bariatric surgery techniques that alter the digestive anatomy also modify the gastric absorption surface. Since alcohol is a substance that is mainly metabolized in the stomach, the goal of this study was to determine alcohol absorption before and after a laparoscopic sleeve gastrectomy (LSG) in the same patients.

Methods

Studies were carried out on 12 morbidly obese patients who underwent a LSG (eight men and four women). Each patient was given 3.6 ml of red wine to drink at 14% for each liter of body water mass. Alcotest values (Alcoscan Alcomate AL-6000) were measured 10 min after the wine dose had been consumed. Measurements were then repeated every 5 min until the alcohol had been completely eliminated from the bloodstream. During the postoperatory period (median of 2.3 months), the measurement was repeated with the total dose per kg adjusted to the new water body mass. The results were measured with a nonparametric analysis for repeated samples.

Results

The maximum average peak of the Alcotest was 2.02 g/l during the postoperative period compared to 0.87 g/l during the preoperative period (p = 0.001 Wilcoxon). At 175 min, the blood alcohol level value reaches zero (0) in all pre-operatory patients, while after surgery, an average value of 0.26 g/l was observed (p = 0.027 Wilcoxon). After 4 h, an Alcotest average of 0.20 g/l was observed in these patients.

Conclusion

Alcohol absorption was considerably modified after LSG with higher and longer blood alcohol values for equivalent amounts of alcohol.

Keywords

Sleeve gastrectomy Alcohol metabolism Alcotest Morbid obesity 

Notes

Conflict of Interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Blanck HM, Dieztz WH, Galuska DA, et al. State specific prevalence of obesity among adults. United States 2005. JAMA. 2006;296:1959–60.CrossRefGoogle Scholar
  2. 2.
    MINSAL. Primera Encuesta Nacional de Salud 2003. Gobierno de Chile. Ministerio de Salud.Google Scholar
  3. 3.
    Adams T, Gress R, Smith S, et al. Long term mortality after gastric bypass surgery. N Engl J Med. 2007;357:753–61.CrossRefPubMedGoogle Scholar
  4. 4.
    National Institutes of Health Consensus Development Conference Panel. Gastrointestinal surgery for severe obesity. Ann Intern Med. 1991;115:956–61.Google Scholar
  5. 5.
    Melissas J, Koukouraki S, Askoxylakis J, et al. Sleeve gastrectomy: a restrictive procedure? Obes Surg. 2007;17:57–62.CrossRefPubMedGoogle Scholar
  6. 6.
    Melissas J, Daskalakis M, Koukouraki S, et al. Sleeve gastrectomy—a “food limiting” operation. Obes Surg. 2008;18:1251–6.CrossRefPubMedGoogle Scholar
  7. 7.
    Braghetto I, Davanzo C, Korn O et al. Scintigraphic evaluation of gastric emptying in obese patients submitted to sleeve gastrectomy compared to normal subjects. Obes Surg. 2009. (Epub ahead of print).Google Scholar
  8. 8.
    Caballeria J, Frezza M, Hernandez-Muñoz R, et al. Gastric origin of the first-pass metabolism of ethanol in humans: effect of gastrectomy. Gastroenterology. 1989;92:1205–9.Google Scholar
  9. 9.
    Jones AW. Body mass index and blood–alcohol calculations. J Anal Toxicol. 2007;31:177–8.PubMedGoogle Scholar
  10. 10.
    Jones AW, Beylich KM, Bjorneboe A, et al. Measuring ethanol in blood and breath for legal purposes: variability between laboratories and between breath-test instruments. Clin Chem. 1992;38:743–7.PubMedGoogle Scholar
  11. 11.
    Linberg L, Brauer S, Wollmer P et al. Breath alcohol concentration determined with a new analyzer using free exhalation predicts almost precisely the arterial blood concentration. Forensic Sci Int, Epub. 2006 Sept 13.Google Scholar
  12. 12.
    Strain GW, Wang J, Gagner M et al. Bioimpedance for severe obesity. Comparing research methods for total body water and resting energy expenditure. Obesity (Silver Spring). 2008, Jun. 12.Google Scholar
  13. 13.
    Klockhoff H, Naeslund I, Jones AW. Faster absorption of ethanol and higher peak concentration in women after gastric bypass surgery. Br J Clin Pharmacol. 2002;54:587–91.CrossRefPubMedGoogle Scholar
  14. 14.
    Hagedorn J, Encarnacion B, Brat G, et al. Does gastric bypass alter alcohol metabolism? Surg Obes Relat Dis. 2007;3:543–8.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science + Business Media, LLC 2010

Authors and Affiliations

  • Fernando Maluenda
    • 1
    • 2
    • 5
    Email author
  • Attila Csendes
    • 2
  • Xabier De Aretxabala
    • 1
    • 2
    • 5
  • Jaime Poniachik
    • 3
  • Karen Salvo
    • 4
    • 5
  • Iris Delgado
    • 5
  • Patricia Rodriguez
    • 4
    • 5
  1. 1.Department of SurgeryGerman Clinic of SantiagoSantiagoChile
  2. 2.Department of SurgeryClinical Hospital University of ChileSantiagoChile
  3. 3.Department of MedicineClinical Hospital University of ChileSantiagoChile
  4. 4.Department of MedicineGerman Clinic of SantiagoSantiagoChile
  5. 5.Faculty of MedicineUniversity of Desarrollo-German ClinicSantiagoChile

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