Alcohol Absorption Modification After a Laparoscopic Sleeve Gastrectomy Due to Obesity
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The different bariatric surgery techniques that alter the digestive anatomy also modify the gastric absorption surface. Since alcohol is a substance that is mainly metabolized in the stomach, the goal of this study was to determine alcohol absorption before and after a laparoscopic sleeve gastrectomy (LSG) in the same patients.
Studies were carried out on 12 morbidly obese patients who underwent a LSG (eight men and four women). Each patient was given 3.6 ml of red wine to drink at 14% for each liter of body water mass. Alcotest values (Alcoscan Alcomate AL-6000) were measured 10 min after the wine dose had been consumed. Measurements were then repeated every 5 min until the alcohol had been completely eliminated from the bloodstream. During the postoperatory period (median of 2.3 months), the measurement was repeated with the total dose per kg adjusted to the new water body mass. The results were measured with a nonparametric analysis for repeated samples.
The maximum average peak of the Alcotest was 2.02 g/l during the postoperative period compared to 0.87 g/l during the preoperative period (p = 0.001 Wilcoxon). At 175 min, the blood alcohol level value reaches zero (0) in all pre-operatory patients, while after surgery, an average value of 0.26 g/l was observed (p = 0.027 Wilcoxon). After 4 h, an Alcotest average of 0.20 g/l was observed in these patients.
Alcohol absorption was considerably modified after LSG with higher and longer blood alcohol values for equivalent amounts of alcohol.
KeywordsSleeve gastrectomy Alcohol metabolism Alcotest Morbid obesity
Conflict of Interest
The authors declare that they have no conflict of interest.
- 2.MINSAL. Primera Encuesta Nacional de Salud 2003. Gobierno de Chile. Ministerio de Salud.Google Scholar
- 4.National Institutes of Health Consensus Development Conference Panel. Gastrointestinal surgery for severe obesity. Ann Intern Med. 1991;115:956–61.Google Scholar
- 7.Braghetto I, Davanzo C, Korn O et al. Scintigraphic evaluation of gastric emptying in obese patients submitted to sleeve gastrectomy compared to normal subjects. Obes Surg. 2009. (Epub ahead of print).Google Scholar
- 8.Caballeria J, Frezza M, Hernandez-Muñoz R, et al. Gastric origin of the first-pass metabolism of ethanol in humans: effect of gastrectomy. Gastroenterology. 1989;92:1205–9.Google Scholar
- 11.Linberg L, Brauer S, Wollmer P et al. Breath alcohol concentration determined with a new analyzer using free exhalation predicts almost precisely the arterial blood concentration. Forensic Sci Int, Epub. 2006 Sept 13.Google Scholar
- 12.Strain GW, Wang J, Gagner M et al. Bioimpedance for severe obesity. Comparing research methods for total body water and resting energy expenditure. Obesity (Silver Spring). 2008, Jun. 12.Google Scholar