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Obesity Surgery

, Volume 20, Issue 6, pp 692–697 | Cite as

Single vs Repeated Treatment with the Intragastric Balloon: A 5-Year Weight Loss Study

  • Jean-Marc DumonceauEmail author
  • Erik François
  • Axel Hittelet
  • Abdel Ilah Mehdi
  • Marie Barea
  • Jacques Deviere
Clinical Research

Abstract

Background

Saline-filled intragastric balloons (IB) may be inserted for 6 months to promote weight loss. We aimed to assess potential benefits of repeating IB therapy.

Methods

One hundred eighteen consecutive subjects (median body mass index, 34.0 kg/m2; interquartile range [IQR], 31.2–36.9) treated with IB were included in a prospective non-randomized multicenter study.

Results

Nineteen (16%) subjects had repeat IB therapy at their own request, either to prolong first treatment (n = 8) or after a IB-free interval (n = 11). Higher weight loss 3 months after first IB insertion independently predicted repeat therapy (P = 0.008). Median weight loss in subjects who had repeat therapy was lower with second vs first IB (9.0 vs 14.6 kg; 30.4% vs 49.3% excess weight [EW]; P = 0.003). Compared to subjects with single treatment (n = 99), those with repeat treatment (n = 19) had greater weight loss at first IB extraction (14.6 vs 11.0 kg; 49.3% vs 30.7% EW; P = 0.026) and 1 year later (12.0 vs 6.0 kg; 40.9% vs 20.8% EW; P = 0.008) but the difference became less than 2 kg starting at 3 years. At final follow-up (4.9 years; IQR, 3.4–6.7), the whole subject population had lost a median of 2.0 kg (IQR, −3.0 to 10.3) or 6.2% EW (IQR, −8.1 to 31.6) and identical proportions of subjects with single/repeat treatment had ≥10% baseline weight loss (26%) or bariatric surgery (32%).

Conclusion

Higher weight loss at 3 months independently predicted repeat IB therapy; weight loss with the second IB was lower compared to first IB. Repeat treatment had no effect on proportions of subjects with ≥10% baseline weight loss or bariatric surgery at final follow-up.

Keywords

Obesity Gastrointestinal endoscopy Gastric balloon Weight loss 

Abbreviations

BMI

body mass index

IB

intragastric balloon

IQR

interquartile range

LOCF

last observation carried forward

Notes

Potential Conflicts of Interests

The authors declare that they have no conflict of interest.

Funding

No funding was obtained for this work.

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Copyright information

© Springer Science + Business Media, LLC 2010

Authors and Affiliations

  • Jean-Marc Dumonceau
    • 1
    • 4
    Email author
  • Erik François
    • 2
  • Axel Hittelet
    • 2
  • Abdel Ilah Mehdi
    • 3
  • Marie Barea
    • 2
  • Jacques Deviere
    • 2
  1. 1.Service of Gastroenterology and HepatologyGeneva University HospitalsGenevaSwitzerland
  2. 2.Department of Gastroenterology and Hepato-PancreatologyErasme University HospitalBrusselsBelgium
  3. 3.Department of Digestive SurgeryErasme University HospitalBrusselsBelgium
  4. 4.Division of Gastroenterology and HepatologyGeneva University HospitalsGenevaSwitzerland

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