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Long-Term Results of Gastric Bypass Surgery in Morbidly Obese Type 1 Diabetes Patients

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Abstract

Background

Long-term effects of bariatric surgery in morbidly obese type 1 patients are unknown. Five to eight-year experience in the case series of type 1 diabetes subjects is presented.

Methods

Three poorly controlled type 1 diabetes patients, aged 19, 23, and 28 underwent Roux-en-Y gastric bypass surgery.

Results

Their maximum body weight reduction noted during the follow-up was between 27% and 31% of baseline body weight, insulin requirement decreased from 0.6–0.95 to 0.3–0.83 IU/kg, and absolute reduction in HbA1c was 3–4%. Significant improvement in blood pressure, plasma lipid profile, and microalbuminuria was noted.

Conclusions

RYGB surgery in morbidly obese type 1 diabetes patients leads to a significant and maintained weight loss and results in remarkable improvement in blood glucose control and concomitant disorders. Bariatric surgery should be recommended to significantly obese type 1 diabetes patients as a means of reduction of vascular complications risk.

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References

  1. Colquitt JL, Picot J, Loveman E, et al. Surgery for obesity. Cochrane Database Syst Rev. 2009;15:CD003641.

    Google Scholar 

  2. Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med. 2009;122:248–56.

    Article  PubMed  Google Scholar 

  3. Czupryniak L, Strzelczyk J, Pawłowski M, et al. Mild elevation of fasting plasma glucose is a strong risk factor for postoperative complications in gastric bypass patients. Obes Surg. 2004;14:1393–7.

    Article  PubMed  Google Scholar 

  4. Alexandrides TK, Skroubis G, Kalfarentzos F. Resolution of diabetes mellitus and metabolic syndrome following Roux-en-Y gastric bypass and a variant of biliopancreatic diversion in patients with morbid obesity. Obes Surg. 2007;17:176–84.

    Article  PubMed  Google Scholar 

  5. Mechanick JI, Kushner RF, Sugerman HJ, et al. American Association of Clinical Endocrinologists; Obesity Society; American Society for Metabolic & Bariatric Surgery. American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery medical guidelines for clinical practice for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient. Obesity. 2009;17 Suppl 1:S1–70.

    PubMed  Google Scholar 

  6. de Boer IH, Kestenbaum B, Rue TC, et al. Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group. Insulin therapy, hyperglycemia, and hypertension in type 1 diabetes mellitus. Arch Intern Med. 2008;22:1867–73.

    Article  Google Scholar 

  7. Pang TT, Narendran P. Addressing insulin resistance in type 1 diabetes. Diabet Med. 2008;25:1015–24.

    Article  CAS  PubMed  Google Scholar 

  8. Potenza MA, Gagliardi S, Nacci C, et al. Endothelial dysfunction in diabetes: from mechanisms to therapeutic targets. Curr Med Chem. 2009;16:94–112.

    Article  CAS  PubMed  Google Scholar 

  9. Bult MJ, van Dalen T, Muller AF. Surgical treatment of obesity. Eur J Endocrinol. 2008;158:135–45.

    Article  CAS  PubMed  Google Scholar 

  10. Meguid MM, Glade MJ, Middleton FA. Weight regain after Roux-en-Y: a significant 20% complication related to PYY. Nutrition. 2008;24:832–42.

    Article  CAS  PubMed  Google Scholar 

  11. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr. 2005;146:693–700.

    Article  PubMed  Google Scholar 

  12. Liu LL, Lawrence JM, Davis C, et al. Prevalence of overweight and obesity in youth with diabetes in USA: the SEARCH for Diabetes in Youth Study. Pediatr Dia. 2009. doi:10.1111/j.1399-5448.2009.00519.x.

    Google Scholar 

  13. Pozzilli P, Guglielmi C. Double diabetes: a mixture of type 1 and type 2 diabetes in youth. Endocr Dev. 2009;14:151–66.

    Article  PubMed  Google Scholar 

  14. Reinehr T, Schober E, Wiegand S, et al. Holl R; DPV-Wiss Study Group. Beta-cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification? Arch Dis Child. 2006;91:473–7.

    Article  CAS  PubMed  Google Scholar 

  15. Rosenbloom AL, Silverstein JH, Amemiya S, et al. ISPAD Clinical Practice Consensus Guidelines 2009 Compendium. Type 2 diabetes in the child and adolescent. Pediatric Dia. 2009;10 Suppl 12:17–32.

    Article  Google Scholar 

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Correspondence to Leszek Czupryniak.

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Czupryniak, L., Wiszniewski, M., Szymański, D. et al. Long-Term Results of Gastric Bypass Surgery in Morbidly Obese Type 1 Diabetes Patients. OBES SURG 20, 506–508 (2010). https://doi.org/10.1007/s11695-010-0074-6

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  • DOI: https://doi.org/10.1007/s11695-010-0074-6

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