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Serum S100B but not NSE Levels are Increased in Morbidly Obese Individuals Affected by Obstructive Sleep Apnea–Hypopnea Syndrome

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Abstract

Background

Obstructive sleep apnea–hypopnea syndrome (OSAHS) is considered a comorbidity associated with morbid obesity, mainly because of the large neck circumference. Depending on its severity, OSAHS can interfere in many homeostasis systems, for example, the central nervous system (CNS). Neuron-specific enolase (NSE) and S100B protein derived from astrocytes are considered sensitive biochemical markers of cerebral injury. We evaluated serum S100B and NSE levels in this study with the aim of detecting possible cerebral injury as a consequence of OSAHS.

Methods

This was a transverse study with data from 25 morbidly obese patients with OSAHS. Blood samples were collected before and after polysomnography (PSG) to determine S100B and NSE protein levels. We also analyzed data evaluating depression and excessive daytime sleepiness.

Results

S100B levels were higher after [0.029 (0.010–0.199) mg/l] compared to before [0.010 (0.010–0.025) mg/l] on PSG (P = 0.002). S100B levels were expressed as means and IQ25–IQ75. NSE levels did not show significant differences before and after PSG.

Conclusion

Our study shows a significant increase in S100B level after PSG compared to before. This suggests that there is a CNS astrocyte reaction because of possible cerebral hypoxemia in morbidly obese patients with OSAHS.

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Abbreviations

OSAHS:

obstructive sleep apnea–hypopnea syndrome

CNS:

central nervous system

S100B:

a protein derived from astrocyte activity

NSE:

neuron-specific enolase (a glycolytic pathway enzyme from CNS)

PSG:

polysomnography

AHI:

apnea–hypopnea index

EDS:

excessive daytime sleepiness

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Acknowledgments

Special thanks for Dr Claudio Corá Mottin; Dr Diogo Onofre Souza; Dr Luiz Valmor Portela and Dr Renato Dutra Dias; for always stimulating the integration between Clinical and Basic Sciences Research.

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Authors and Affiliations

  1. Av. Ipiranga 6690/302, Porto Alegre, RS, 90610-000, Brazil

    Leandro Giacometti da Silva

  2. Centro da Obesidade Mórbida, Hospital São Lucas da PUCRS (COM HSL/PUCRS), Porto Alegre, Brazil

    Leandro Giacometti da Silva, Cláudio Corá Mottin, Carolina Boeira Vargas & Alexandre Vontobel Padoin

  3. Faculdade de Biociências—PUCRS, Porto Alegre, Brazil

    Leandro Giacometti da Silva, Luiz Valmor Portela & Renato Dutra Dias

  4. Departamento de Bioquímica—UFRGS, Porto Alegre, Brazil

    Diogo Onofre Souza & Carla Winei Braga

  5. Clínica do Sono, Porto Alegre, RS, Brazil

    Denis Martinez

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  1. Leandro Giacometti da Silva
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  2. Cláudio Corá Mottin
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Correspondence to Leandro Giacometti da Silva.

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da Silva, L.G., Mottin, C.C., Souza, D.O. et al. Serum S100B but not NSE Levels are Increased in Morbidly Obese Individuals Affected by Obstructive Sleep Apnea–Hypopnea Syndrome. OBES SURG 18, 993–999 (2008). https://doi.org/10.1007/s11695-007-9386-6

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  • DOI: https://doi.org/10.1007/s11695-007-9386-6

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