The Increase in Serum Visfatin After Bariatric Surgery in Morbidly Obese Women is Modulated by Weight Loss, Waist Circumference, and Presence or Absence of Diabetes Before Surgery
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Previous studies addressing the changes in serum visfatin levels after bariatric surgery yielded conflicting results.
We measured serum visfatin levels in 41 morbidly obese women before bariatric surgery and after losing at least 15% of the initial weight, and analyzed the results taking into account the type of surgery, reproductive and diabetic status, among others. Body mass index, waist circumference, lipid profile, and insulin resistance determined by homeostasis model assessment (HOMA-IR) were also measured.
Patients lost 30.3 ± 6.1% of the initial body weight, and serum visfatin levels increased from 22.2 ± 20.9 to 32.2 ± 27.6 ng/ml (P = 0.031). A multiple regression model (R2 = 0.314, F = 3.555, P = 0.017) including the percentage of weight loss, changes in waist circumference, HOMA-IR, high-density lipoprotein-cholesterol, and triglycerides (also expressed as percentage from baseline), the surgical procedure, time elapsed since surgery, and previous diabetic status as independent variables showed that weight loss (β = −0.670, P = 0.010), previous diabetic status (β = −0.330, P = 0.036), and change in waist circumference (β = 0.556, P = 0.031) were the main determinants of the percentual increase in serum visfatin levels observed after bariatric surgery.
Serum visfatin increased after bariatric surgery in relation to the amount of weight lost and to the changes in waist circumference, and this increase was higher in diabetic patients.
KeywordsVisfatin Bariatric surgery Morbid obesity Diabetes mellitus Weight loss Polycystic ovary syndrome Insulin resistance
- 15.Tan BK, Chen J, Digby JE, Keay SD, Kennedy CR, Randeva HS. Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: parallel increase in plasma visfatin. J Clin Endocrinol Metab. 2006;91:5022–8.PubMedCrossRefGoogle Scholar
- 18.Zawadzki JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: toward a rational approach. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, editors. Polycystic ovary syndrome. Boston: Blackwell Scientific Publications; 1992. pp. 377–84.Google Scholar
- 19.Botella-Carretero J, Alvarez-Blasco F, Martinez-Garcia MA, Luque-Ramirez M, San Millan JL, Escobar-Morreale HF. The decrease in serum IL-18 levels after bariatric surgery in morbidly obese women is a time-dependent event. Obes Surg. 2007;17:1199–208.Google Scholar
- 38.Prins JB, O’Rahilly S. Regulation of adipose cell number in man. Clin Sci (Lond). 1997;92:3–11.Google Scholar