Abstract
Background
Short time overfeeding of rats rapidly leads to insulin resistance (IR). A study with healthy human volunteers, which we suggest are less susceptible for developing IR after short time overfeeding, did not show these effects on IR. Therefore a study population of weight-stable, former morbidly obese subjects (BMI 31.3 kg/m2), which were treated with bariatric surgery approximately 3 years ago was selected.
Methods
Eleven subjects were submitted to a 7-day overfeeding study, resulting in a 53% increase in caloric intake (1,227 ± 394.4 to 1,879.2 ± 298.4 kcal/day). During normal diet and after overfeeding, insulin sensitivity was measured using steady state plasma glucose (SSPG) levels. At these time points, BMI and waist/hip ratio together with plasma levels of inflammatory markers (CRP, AGP, LBP, and TNF-α receptors) and plasma leptin values were also measured.
Results
SSPG levels after overfeeding increased from 8.2 ± 3.2 to 10.6 ± 2.6 mmol/l (P < 0.05), indicating decreased insulin sensitivity after overfeeding. Fasting plasma insulin, glucose, circulating levels of inflammatory markers, BMI, and waist/hip ratio remained unchanged.
Conclusions
This study shows that overfeeding in a group of weight-stable, former morbidly obese subjects 3 years after bariatric surgery results in decreased insulin sensitivity. The mechanisms behind decreased insulin sensitivity induced by overfeeding are poorly understood, but the present results reveal that a unique human model is available to study these mechanisms, leading to a better understanding of the pathophysiology of IR.
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Nijhuis, J., van Dielen, F.M.H., Schaper, N.C. et al. Short-term Overfeeding Induces Insulin Resistance in Weight-stable Patients After Bariatric Surgery. OBES SURG 18, 300–305 (2008). https://doi.org/10.1007/s11695-007-9306-9
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DOI: https://doi.org/10.1007/s11695-007-9306-9