Abstract
Breast cancer metastasis is a complex and still weakly understood process that involves diverse cellular pathways. It accounts for the majority of deaths from breast cancer. Recently, microRNAs (miRNAs), small non-coding RNAs that regulate gene expression post-transcriptionally, have been shown to be involved in breast cancer metastasis. In particular, in a recent work it has been found that miR-429 may have a role in the inhibition of migration and invasion of breast cancer cells. Its target gene CRKL has been identified as a potential candidate. In this paper, by using systems biology tools we have shown that CRKL is involved in positive regulation of ERK1/2 signaling pathway and contribute to the regulation of LYN through a topological generalization of feed forward loop.
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Notes
IntAct is one of the largest available repositories for curated molecular interactions data, storing PPIs as well as interactions involving other molecules. It is hosted by the European Bioinformatics Institute. IntAct has evolved into a multisource curation platform and many other databases curate into IntAct and make their data available through it (Sandra et al. 2014).
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Chafik, A. The role of CRKL in breast cancer metastasis: insights from systems biology. Syst Synth Biol 9, 141–146 (2015). https://doi.org/10.1007/s11693-015-9180-z
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DOI: https://doi.org/10.1007/s11693-015-9180-z