Boolean network model for GPR142 against Type 2 diabetes and relative dynamic change ratio analysis using systems and biological circuits approach

Kaushik, Aman Chandra; Sahi, Shakti

doi:10.1007/s11693-015-9163-0

Research Article
Published: 14 March 2015

Boolean network model for GPR142 against Type 2 diabetes and relative dynamic change ratio analysis using systems and biological circuits approach

Aman Chandra Kaushik¹ &
Shakti Sahi¹

Systems and Synthetic Biology volume 9, pages 45–54 (2015)Cite this article

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Abstract

Systems biology addresses challenges in the analysis of genomics data, especially for complex genes and protein interactions using Meta data approach on various signaling pathways. In this paper, we report systems biology and biological circuits approach to construct pathway and identify early gene and protein interactions for predicting GPR142 responses in Type 2 diabetes. The information regarding genes, proteins and other molecules involved in Type 2 diabetes were retrieved from literature and kinetic simulation of GPR142 was carried out in order to determine the dynamic interactions. The major objective of this work was to design a GPR142 biochemical pathway using both systems biology as well as biological circuits synthetically. The term ‘synthetically’ refers to building biological circuits for cell signaling pathway especially for hormonal pathway disease. The focus of the paper is on logical components and logical circuits whereby using these applications users can create complex virtual circuits. Logic gates process represents only true or false and investigates whether biological regulatory circuits are active or inactive. The basic gates used are AND, NAND, OR, XOR and NOT gates and Integrated circuit composition of many such basic gates and some derived gates. Biological circuits may have a futuristic application in biomedical sciences which may involve placing a micro chip in human cells to modulate the down or up regulation of hormonal disease.

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School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India
Aman Chandra Kaushik & Shakti Sahi

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Aman Chandra Kaushik
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Shakti Sahi
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Correspondence to Shakti Sahi.

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Kaushik, A.C., Sahi, S. Boolean network model for GPR142 against Type 2 diabetes and relative dynamic change ratio analysis using systems and biological circuits approach. Syst Synth Biol 9, 45–54 (2015). https://doi.org/10.1007/s11693-015-9163-0

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Received: 20 October 2014
Revised: 04 February 2015
Accepted: 02 March 2015
Published: 14 March 2015
Issue Date: June 2015
DOI: https://doi.org/10.1007/s11693-015-9163-0

Keywords

Biological circuits
BioLogic
GPR142
Systems biology
Type 2 diabetes