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On Brucella pathogenesis: looking for the unified challenge in systems and synthetic biology


Brucellosis is a zoonotic infection transmitted to humans from infected animals and is one of the widely spread zoonoses. Recently, six species were recognized within the genus Brucella wherein B. melitensis, B. suis and B. abortus are considered virulent for humans. While these species differ phenotypically by their pattern of metabolic activities, there has been an imperative need to understand pathogenesis of Brucella species. It has been foreseen that creating a human vaccine for Brucellosis would entail decreased dose of antibiotics. However the emerging role of Brucella pathogenesis still centers on isolation of the organism and various diagnostic tests thereby leading to varying strategies of treatment cycle. In view of disease heterogeneity, we focus systems and synthetic biology challenges that might improve our understanding the Brucella pathogenesis.

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Fig. 1


  • CRISPR Database.

  • de Barsy M, Greub G (2013) Functional genomics of intracellular bacteria. Brief Funct Genomics 12(4):341–353

    Article  PubMed  Google Scholar 

  • Hanna N, de Bagüés MPJ, Ouahrani-Bettache S, El Yakhlifi Z, Köhler S, Occhialini A (2011) The virB operon is essential for lethality of Brucella microti in the Balb/c murine model of infection. J Infect Dis 203(8):1129–1135

    Article  CAS  PubMed  Google Scholar 

  • Lacerda TL, Salcedo SP, Gorvel JP (2013) Brucella T4SS: the VIP pass inside host cells. Curr Opin Microbiol 16(1):45–51

    Article  CAS  PubMed  Google Scholar 

  • Liang L, Tan X, Juarez S, Villaverde H, Pablo J, Nakajima-Sasaki R, Gotuzzo E, Saito M, Hermanson G, Molina D, Felgner S, Morrow WJ, Liang X, Gilman RH, Davies DH, Tsolis RM, Vinetz JM, Felgner PL (2011) Systems biology approach predicts antibody signature associated with Brucella melitensis infection in humans. J Proteome Res 10(10):4813–4824

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Liu WJ, Dong H, Peng XW, Wu QM (2014) The cyclic AMP-binding protein CbpB in Brucella melitensis and its role in cell envelope integrity, resistance to detergent and virulence. FEMS Microbiol Lett 356(1):79–88

    Article  CAS  PubMed  Google Scholar 

  • Moreno E (2014) Retrospective and prospective perspectives on zoonotic brucellosis. Front Microbiol 13(5):213

    Google Scholar 

  • Padiadpu J, Vashisht R, Chandra N (2010) Protein-protein interaction networks suggest different targets have different propensities for triggering drug resistance. Syst Synth Biol 4(4):311–322

    Article  PubMed Central  PubMed  Google Scholar 

  • Seven neglected endemic zoonoses -some basic facts.

  • Shevtsov A, Tarlykov P, Zholdybayeva E, Shevtsova E, Momynkulov D, Sytnik I, Karibaev T, Chsherbakov A, Momynaliev K (2013) Draft genome sequence of the live vaccine strain Brucella abortus 82. Genome Announc 1(6):e01101

  • Shidhi PR, Nair AS, Suravajhala P (2014) Identifying pseudogenes from hypothetical proteins for making synthetic proteins. Syst Synth Biol 8(2):169–171

    Article  CAS  PubMed  Google Scholar 

  • Shome R, Krithiga N, Muttannagouda RB et al (2013) Draft genome sequence of Brucella melitensis strain ADMAS-G1, isolated from placental fluids of an aborted goat. Genome Announc 1(5):e00809

  • Tian M, Qu J, Han X, Zhang M, Ding C, Ding J, Chen G, Yu S (2013) Microarray-based identification of differentially expressed genes in intracellular Brucella abortus within RAW2647 cells. PLoS One 8(8):67014

    Article  Google Scholar 

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Correspondence to Prashanth Suravajhala.

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Chiliveru, S., Appari, M. & Suravajhala, P. On Brucella pathogenesis: looking for the unified challenge in systems and synthetic biology. Syst Synth Biol 9, 73–75 (2015).

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  • Brucellosis
  • Pathogensis
  • Systems biology
  • Synthetic biology
  • Challenges