Biased Polyphenism in Polydactylous Cats Carrying a Single Point Mutation: The Hemingway Model for Digit Novelty

Abstract

Point mutations in a cis-regulatory element of Sonic Hedgehog are frequently associated with preaxial polydactyly in humans, mice, and cats. The Hemingway mutant in the Maine Coon cat exhibits polyphenic effects of polydactyly that are not equally distributed. A statistical analysis of a comprehensive data base of Hemingway mutants reveals a biased and discontinuous distribution of extra digits. Further biases exist in the difference of effects in fore- versus hind-limbs and in left–right asymmetry. These non-equally distributed phenotypic effects cannot be explained by the point mutation alone. We propose a double mapping model, termed the Hemingway Model, to account for the biased distribution of supernumerary digits. The model is based on the random bistability of individual cells in the limb area affected by the mutation and on the application of the Central Limit Theorem. It proposes two kinds of mapping events that (a) transform a mutational effect of single additive changes into a continuous distribution, and (b) transform the continuous distribution into discrete character states via developmental threshold effects. The threshold widths for the occurrence of discrete extra digits are specified as units of standard deviations of the continuous variable. This makes it possible to specify the generation of empirical developmental variables (the liability of quantitative genetics) as a result of developmental parameters that give rise to biased morphological patterns and phenotypic novelty.

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Acknowledgments

We thank the PolyTrak team, especially K. Bussard, USA, and V. Bode, Netherlands, for technical assistance with using PolyTrak. We also thank the experienced Maine Coon breeders, M. Roth and P. Nagl in Germany and S. Otten-Boult in the Netherlands, for their valuable support and patience in answering our questions. P. Shevtsova, a Maine Coon breeder in Moscow, provided the picture of the Hemingway mutant. The X-rays are reproduced with kind permission from S. Otten-Boult. We also express our thanks to two anonymous reviewers for their valuable comments and to Tim Peterson for help with the elements of style.

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Lange, A., Nemeschkal, H.L. & Müller, G.B. Biased Polyphenism in Polydactylous Cats Carrying a Single Point Mutation: The Hemingway Model for Digit Novelty. Evol Biol 41, 262–275 (2014). https://doi.org/10.1007/s11692-013-9267-y

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Keywords

  • Polydactyly
  • Polyphenism
  • Limb development
  • Central Limit Theorem
  • Developmental thresholds
  • Evolutionary innovation
  • Phenotypic novelty