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Acide arachidonique et prostaglandines : impact sur la formation des adipocytes blancs, bruns et brites/beiges

Arachidonic acid and prostaglandins: impact on white, brown and brite/beige adipocyte formation

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Obésité

Résumé

Les adipocytes blancs stockent et libèrent l’énergie à la demande alors que les adipocytes brites (ou beiges) et bruns la dissipent sous forme de chaleur. Nous décrivons ici les effets de l’acide arachidonique (ARA) et de ses métabolites sur la formation de ces adipocytes, en mettant en avant la complexité et la dualité de ces effets. Ces données démontrent l’importance de la biodisponibilité de l’ARA dans la biologie du tissu adipeux et les pathologies qui lui sont associées.

Abstract

White adipocytes store and release energy upon request whereas brown and brite (or beige) adipocytes dissipate it as heat. Herein, we describe the effects of arachidonic acid (ARA) and its metabolites on the formation of white and brites adipocytes, highlighting the complexity and duality of these effects. These observations demonstrate the importance of the bioavailability of ARA in the adipose tissue biology and its associated diseases.

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Authors and Affiliations

  1. iBV, UMR 7277, Univ. Nice Sophia Antipolis, 06100, Nice, France

    R. A. Ghandour, D. F. Pisani & E. -Z. Amri

  2. Faculté de Médecine, 28 av. de Valombrose, 06107, Nice cedex 2, France

    R. A. Ghandour, D. F. Pisani & E. -Z. Amri

  3. CNRS, iBV UMR 7277, 06100, Nice, France

    R. A. Ghandour, D. F. Pisani & E. -Z. Amri

  4. Inserm, iBV, U1091, 06100, Nice, France

    R. A. Ghandour, D. F. Pisani & E. -Z. Amri

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  1. R. A. Ghandour
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  3. E. -Z. Amri
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Correspondence to E. -Z. Amri.

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Ghandour, R.A., Pisani, D.F. & Amri, E.Z. Acide arachidonique et prostaglandines : impact sur la formation des adipocytes blancs, bruns et brites/beiges. Obes 11, 159–167 (2016). https://doi.org/10.1007/s11690-016-0525-x

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  • DOI: https://doi.org/10.1007/s11690-016-0525-x

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