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Modulation de la sensibilité à l’insuline par les adapteurs moléculaires de la famille de Grb7

Modulation of insulin sensitivity by the Grb7 family of molecular adaptors

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Obésité

Résumé

Les protéines de la famille de Grb7 (growth factor binding protein 7), dont Grb10 et Grb14, sont récemment apparues comme étant des inhibiteurs de l’action de l’insuline. Leur rôle a été démontré à l’aide de modèles génétiques murins. Le mécanisme moléculaire de l’action de ces régulateurs implique à la fois un effet direct sur l’activité catalytique du récepteur de l’insuline et des effets plus en aval dans les voies de signalisation. L’inhibition pharmacologique de l’action de Grb10/14 pourrait être une approche innovante pour améliorer la sensibilité à l’insuline et la régulation de l’homéostasie énergétique.

Abstract

The Grb7 family of proteins recently emerged as inhibitors of insulin action. The generation of genetic mouse models allowed demonstrating their physiological role in the control of insulin sensitivity and energy metabolism. Their molecular mechanism of action involves a direct inhibition of the insulin receptor catalytic activity and also more distal interferences in insulin signaling pathways that are not yet fully described. The pharmacological inhibition of Grb10/14 action could be a new approach to improve insulin sensitivity and glucose homeostasy.

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Authors and Affiliations

  1. Inserm U1016, Institut Cochin, Paris, France

    N. Carré, D. Goenaga & A. -F. Burnol

  2. Cnrs, UMR8104, Paris, France

    N. Carré, D. Goenaga & A. -F. Burnol

  3. Univ Paris Descartes, Paris, France

    N. Carré, D. Goenaga & A. -F. Burnol

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  1. N. Carré
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  2. D. Goenaga
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  3. A. -F. Burnol
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Correspondence to A. -F. Burnol.

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Carré, N., Goenaga, D. & Burnol, A.F. Modulation de la sensibilité à l’insuline par les adapteurs moléculaires de la famille de Grb7. Obes 6, 114–122 (2011). https://doi.org/10.1007/s11690-011-0280-y

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  • DOI: https://doi.org/10.1007/s11690-011-0280-y

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