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Pathologies rénales liées à l’obésité

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Obésité

Résumé

L’obésité est un facteur de risque indépendant de maladie rénale chronique et d’insuffisance rénale chronique (IRC) terminale. Les lésions histologiques les plus fréquentes sont la glomérulomégalie et l’hyalinose segmentaire et focale, le pronostic de cette dernière étant meilleur que la forme idiopathique. Les mécanismes physiopathologiques impliquent des modifications de l’hémodynamique glomérulaire ainsi qu’une activation de nombreuses cytokines et de facteurs de croissance par le biais de l’hyperlipidémie, de l’hyperinsulinémie et de l’augmentation de la leptine.

Abstract

Obesity is now recognized as an independent risk factor for chronic kidney disease and end-stage renal failure. The most frequent histological lesions are glomerulomegaly and focal and segmental glomerulosclerosis, the latter having a better evolution than the idiopathic form. Mechanisms leading to these lesions involve modifications of the glomerular hemodynamic and activation of many cytokines and growth factors secondary to hyperlipidemia, hyperinsulinemia and hyperleptinemia.

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Authors and Affiliations

  1. Service de néphrologie, dialyse, transplantation, CHU de Limoges, F-87000, Limoges, France

    G. Ensergueix & M. Essig

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  1. G. Ensergueix
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  2. M. Essig
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Correspondence to M. Essig.

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Ensergueix, G., Essig, M. Pathologies rénales liées à l’obésité. Obes 6, 3–6 (2011). https://doi.org/10.1007/s11690-011-0253-1

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  • DOI: https://doi.org/10.1007/s11690-011-0253-1

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