Consommation de fructose: facteur déclenchant du syndrome métabolique ?

Fructose consumption: a possible trigger for metabolic syndrome?


Le fructose est un sucre simple, dont la consommation a augmenté durant les dernières décennies, principalement par le biais d’une hausse de consommation de boissons sucrées. Chez le rongeur comme chez l’humain, un régime riche en fructose provoque expérimentalement de nombreuses altérations métaboliques, telles qu’une dyslipidémie, une résistance hépatique et musculaire à l’insuline et une déposition de lipides ectopiques. Ces effets mettent en avant le rôle délétère que pourrait avoir une alimentation riche en fructose dans la vie courante.


Fructose is a simple sugar, whose consumption has increased over the past decades, mainly due to an increased consumption of soft drinks and other sugar-sweetened food items. In both rodents and humans, a high fructose diet experimentally induces several features of metabolic syndrome, such as dyslipidemia, hepatic and muscle insulin resistance, and ectopic lipid deposition. These effects suggest that fructose may play a role in diet-induced metabolic disorders.

This is a preview of subscription content, access via your institution.


  1. 1.

    Elliott SS, Keim NL, Stern JS, et al. (2002) Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76: 911–922

    PubMed  CAS  Google Scholar 

  2. 2.

  3. 3.

    Mayes PA (1993) Intermediary metabolism of fructose. AJCN 58/(suppl): 754S–765S

    Google Scholar 

  4. 4.

    Schwarz JM, Acheson KJ, Tappy L, et al. (1992) Thermogenesis and fructose metabolism in humans. AJP 262: E591–E598

    CAS  Google Scholar 

  5. 5.

    Pagliassotti MJ, Horton TJ (2004) Sucrose, insulin action and biologic complexity. Rec Res Dev Physiol 2: 337–353

    CAS  Google Scholar 

  6. 6.

    Le KA, Tappy L (2006) Metabolic effects of fructose. Curr Opin Clin Nutr Metab Care 9: 469–475

    PubMed  CAS  Google Scholar 

  7. 7.

    Faeh D, Minehira K, Schwarz J, et al. (2005) Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy males. Diabetes 54: 1907–1913

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Le KA, Faeh D, Stettler R, et al. (2006) A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans. Am J Clin Nutr 84: 1374–1379

    PubMed  CAS  Google Scholar 

  9. 9.

    Parks EJ, Hellerstein MK (2000) Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. AJCN 71: 412–433

    CAS  Google Scholar 

  10. 10.

    Roberts R, Bickerton AS, Fielding BA, et al. (2008) Reduced oxidation of dietary fat after a short term high-carbohydrate diet. Am J Clin Nutr 87: 824–831

    PubMed  CAS  Google Scholar 

  11. 11.

    Couchepin C, Le KA, Bortolotti M, et al. (2008) Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjects. Diabetes Care 31: 1254–1256

    PubMed  Article  CAS  Google Scholar 

  12. 12.

    Le KA, Faeh D, Ith M, et al. (2008) Effects of a 6-day high fructose diet on insulin sensitivity and liver fat in healthy males with a family history of type 2 diabetes. Diabetes 57(S1): A11

    Google Scholar 

  13. 13.

    Teff KL, Elliott SS, Tschöp M, et al. (2004) Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 89: 2963–2972

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Busserolles J, Gueux E, Rock E, et al. (2003) High fructose feeding of magnesium deficient rats is associated with increased plasma triglyceride concentration and increased oxidative stress. Magnesium Res 16: 7–12

    CAS  Google Scholar 

  15. 15.

    Keller U (1989) The sugar substitutes fructose and sorbite: an unnecessary risk in parenteral nutrition. Schweiz Med Wochenschr 119: 101–106

    PubMed  CAS  Google Scholar 

  16. 16.

    Seematter G, Tappy L (2007) Effect of nutritional support on glucose control. Curr Opin Clin Nutr Metab Care 10: 210–214

    PubMed  Article  Google Scholar 

  17. 17.

    Ling PR, Smith RJ, Bistrian BR (2007) Acute effects of hyperglycemia and hyperinsulinemia on hepatic oxidative stress and the systemic inflammatory response in rats. Crit Care Med 35: 555–560

    PubMed  Article  CAS  Google Scholar 

  18. 18.

    Popkin BM, Armstrong LE, Bray GM, et al. (2006) A new proposed guidance system for beverage consumption in the United States. Am J Clin Nutr 83: 529–542

    PubMed  CAS  Google Scholar 

  19. 19.

    Striegel-Moore RH, Thompson D, Affenito SG, et al. (2006) Correlates of beverage intake in adolescent girls: the National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr 148: 183–187

    PubMed  Article  Google Scholar 

  20. 20.

    Busserolles J, Gueux E, Rock E, et al. (2002) Substituting honey for refined carbohydrates protects rats from hypertriglyceridemic and pro-oxidative effects of fructose. J Nutr 132: 3379–3382

    PubMed  CAS  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to K. -A. Lê.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lê, K.A. Consommation de fructose: facteur déclenchant du syndrome métabolique ?. Obes 3, 276 (2008).

Download citation

Mots clés

  • Sucres simples
  • Triglycérides
  • Lipides ectopiques
  • Résistance à l’insuline


  • Simple sugars
  • Triglycerides
  • Ectopic lipids
  • Insulin resistance