Consommation de fructose: facteur déclenchant du syndrome métabolique ?

Fructose consumption: a possible trigger for metabolic syndrome?

Résumé

Le fructose est un sucre simple, dont la consommation a augmenté durant les dernières décennies, principalement par le biais d’une hausse de consommation de boissons sucrées. Chez le rongeur comme chez l’humain, un régime riche en fructose provoque expérimentalement de nombreuses altérations métaboliques, telles qu’une dyslipidémie, une résistance hépatique et musculaire à l’insuline et une déposition de lipides ectopiques. Ces effets mettent en avant le rôle délétère que pourrait avoir une alimentation riche en fructose dans la vie courante.

Abstract

Fructose is a simple sugar, whose consumption has increased over the past decades, mainly due to an increased consumption of soft drinks and other sugar-sweetened food items. In both rodents and humans, a high fructose diet experimentally induces several features of metabolic syndrome, such as dyslipidemia, hepatic and muscle insulin resistance, and ectopic lipid deposition. These effects suggest that fructose may play a role in diet-induced metabolic disorders.

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Correspondence to K. -A. Lê.

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Lê, K.A. Consommation de fructose: facteur déclenchant du syndrome métabolique ?. Obes 3, 276 (2008). https://doi.org/10.1007/s11690-008-0160-2

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Mots clés

  • Sucres simples
  • Triglycérides
  • Lipides ectopiques
  • Résistance à l’insuline

Keywords

  • Simple sugars
  • Triglycerides
  • Ectopic lipids
  • Insulin resistance