Résumé
Les relations entre adipocytes et polluants ne se limiteraient pas à un simple stockage moléculaire, les polluants suivant les mouvements des acides gras au gré des alternances des états de lipolyse et de lipogenèse: l’étude menée in vitro sur des souris confirme que la présence de faibles quantités de benzo(a)pyrène (B[a]P) dans l’alimentation ou dans l’environnement de l’animal induit une prise de poids significative dès les premiers jours de l’exposition. L’étude in vitro sur des adipocytes isolés de souris montre que le phénomène est en lien avec un dysfonctionnement de récepteurs transmembranaires (β-récepteurs, récepteurs MC2-R). De récents résultats mettent en cause l’accumulation des polluants dans la membrane cellulaire, provoquant une modification de l’intégrité de ces récepteurs spécifiques. Le caractère ubiquitaire du phénomène est par ailleurs souligné.
Abstract
The relationship between adipocytes and pollutants does not appear to be limited to molecular storage only, as pollutants follow the movements of fatty acids as they alternate between lipolysis and lipogenesis: an in vitro study in mice confirms that the presence of small quantities of benzoapyrene in the animal’s food or environment gives rise to significant weight gain from the very first days of exposure. An in vitro study of isolated mouse adipocytes shows that the phenomenon is linked to a malfunction of transmembrane receptors (β receptors, MC2-R receptors). Recent results suggest that an accumulation of pollutants in the cell membrane might affect the integrity of these particular receptors. The phenomenon’s ubiquitous nature is also emphasised.
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Amoussou, B., Guivarch, Y., Heidi, H. et al. Les 10es Entretiens de nutrition, institut Pasteur de Lille L’obésité, une maladie nutritionnelle. Obes 3, 128–132 (2008). https://doi.org/10.1007/s11690-008-0147-z
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DOI: https://doi.org/10.1007/s11690-008-0147-z