Résumé
Au cours du développement, à l’héritage génétique inscrit dans les gènes, vient s’ajouter une programmation par des processus épigénétiques — qui modulent de manière définitive ou transitoire l’expression spatiotemporelle des gènes sans modifier leur séquence. De manière concomitante, une multitude de facteurs environnementaux comme l’environnement intra-utérin, aux effets délétères mais aussi protecteurs, interfèrent avec les processus épigénétiques, eux-mêmes en interaction permanente avec le fond génétique, le dimorphisme sexuel et les rythmes circadiens.
Abstract
A person’s phenotype is the result of complex interactions between genotype, epigenome and current, past and ancestral environment, which lead to a lifelong remodelling of our epigenomes. Depending on the nature and intensity of the insult the critical spatiotemporal windows and developmental or lifelong processes involved, these epigenetic alterations can lead to permanent changes in tissue and organ structure and function, or, to reversible changes — using appropriate epigenetic tools — which may even be passed on to the next generation.
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Ce texte correspond à une conférence faite par l’auteur, il n’a donc pas été soumis à l’appréciation du comité de rédaction.
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Junien, C. Les 10es Entretiens de Nutrition, Institut Pasteur de Lille L’obésité, une maladie nutritionnelle ?. Obes 3, 124–127 (2008). https://doi.org/10.1007/s11690-008-0128-2
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DOI: https://doi.org/10.1007/s11690-008-0128-2