Obésité

, Volume 3, Issue 2, pp 66–71 | Cite as

La leptine: un lien entre obésité et cancer du sein

  • J. -P. Peyrat
  • F. Révillion
  • J. Grosjean
  • M. Charlier
  • J. Djiane
Dossier Thématique / Thematic File

Résumé

Les liens entre obésité et cancer du sein pourraient résulter de l’action d’adipokines produites par les cellules adipeuses. Parmi ces adipokines, la leptine semble jouer un rôle important. La présence de ses récepteurs sur les cellules de cancers du sein montre qu’elle peut agir directement sur ces cellules: elle est de fait capable de stimuler leur prolifération. Les voies d’action empruntées sont endocrine, paracrine et autocrine. De plus, la leptine serait capable de s’opposer aux traitements anti-estrogéniques. Ces observations suggèrent que le blocage de la leptine aurait un intérêt thérapeutique dans les cancers du sein.

Mots clés

Leptine Obésité Cancer du sein 

Leptin: a link between obesity and breast cancer

Abstract

Links between obesity and breast cancer could result from the action of adipokines produced by adipocytes. Among these adipokines, leptin appears to have an important role. The presence of its receptors on breast cancer cells shows that it can act directly on these cells: it is able to stimulate their proliferation. There are three distinct modes of action through endocrine-, paracrine-, and autocrine-mediated pathways. Moreover, leptin would appear to be able to counteract anti-estrogenic treatments. These observations suggest that it could be of therapeutic interest to target leptin in breast cancer.

Keywords

Leptin Obesity Breast cancer 

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Copyright information

© Springer Paris 2008

Authors and Affiliations

  • J. -P. Peyrat
    • 1
  • F. Révillion
    • 1
  • J. Grosjean
    • 1
    • 2
  • M. Charlier
    • 3
  • J. Djiane
    • 3
  1. 1.Laboratoire d’oncologie moléculaire humainecentre Oscar-LambretLille cedexFrance
  2. 2.Centre hospitalier de ValenciennesValenciennes cedexFrance
  3. 3.Unité de neuroendocrinologie moléculaire de la prise alimentaireInstitut National de la Recherche AgronomiqueJouy-en-Josas cedexFrance

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