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Retard de croissance intra-utérin, petit poids de naissance et risque métabolique

Intrauterine growth restriction, low birth weight and metabolic risk factors

  • Dossier Thématique / Thematic File
  • Published:
Obésité

Résumé

Depuis 15 ans, il est établi que la restriction de croissance fœtale aboutissant à un petit poids de naissance (PPN) module le risque de développer un diabète de type 2 ou des maladies cardiovasculaires. L’apparition précoce d’une insulino-résistance semble l’élément clé de ce phénomène. Son histoire naturelle reste cependant mal connue mais semble relier l’environnement nutritionnel intra-utérin, le rattrapage staturo-pondéral et les modifications métaboliques qui s’y associent et le tissu adipeux.

Abstract

Over the past 15 years, the metabolic and cardiovascular risk factors associated with low birth weight have been identified. They all appear to result from the early onset of insulin resistance. Although the mechanisms and natural history of early insulin resistance remain unclear, some evidence suggests a combination of poor foetal nutritional environment, postnatal catch-up growth and changes in adipose tissue metabolism.

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Authors and Affiliations

  1. Inserm, U690, hôpital Robert-Debré, 48, boulevard Sérurier, F-75019, Paris, France

    J. Beltrand & C. Levy-Marchal

  2. Université Paris-VII, F-75005, Paris, France

    J. Beltrand & C. Levy-Marchal

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  1. J. Beltrand
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  2. C. Levy-Marchal
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Correspondence to J. Beltrand.

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Beltrand, J., Levy-Marchal, C. Retard de croissance intra-utérin, petit poids de naissance et risque métabolique. Obes 2, 166–172 (2007). https://doi.org/10.1007/s11690-007-0050-z

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