Abstract
Introduction
Owing to evolution of parasite strains that are resistant to existing antimalarial drugs, research for novel antimalarial medicines is progressing on numerous fronts.
Purpose
Herein, we evaluated the in vivo anti-Plasmodium berghei activity of β-ionone including its ameliorative potential towards P. berghei-associated anaemia and oxidative organ damage.
Methods
Mice were infected with chloroquine-sensitive strain of P. berghei and then treated with β-ionone at doses of 10 and 20 mg/kg body weight (BW) for seven days. The parasitemia, packed cell volume and redox sensitive biomarkers in the liver, brain and spleen were estimated.
Results
Our result showed that β-ionone, in a dose-dependent fashion, significantly (p < 0.05) repressed the multiplication of P. berghei. More so, the compound, at doses of 10 and 20 mg/kg BW, significantly (p < 0.05) mitigated anaemia and organ damage induced by P. berghei.
Conclusion
Overall, the findings demonstrated that β-ionone has antiplasmodial actions and plays a mitigative role against P. berghei-induced anaemia and oxidative organ damage.
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Data Availability
Not applicable.
References
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Acknowledgements
The authors are grateful to Dr. Mohammed Auwal Ibrahim, Mr. Suleiman Aminu and the management of Ahmadu Bello University, Zaria, Nigeria for critical review of the manuscript, provision of β-ionone and study facilities, respectively.
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MAU and MAS: conceptualised the research study and designed the experiments. FBI, HM, SOA and UAI: conducted all the laboratory experiments. MAU and MAS: supervised the work. MAU, FBI, H-OM, SOA and UAI: analyzed the data. MAU: wrote the manuscript. MAS, FBI, H-OM, SOA and UAI: revised the manuscript. All authors approved the final version of the manuscript.
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Usman, M.A., Ibrahim, F.B., Mohammed, HO. et al. Antiplasmodial Activity of β-Ionone and the Effect of the Compound on Amelioration of Anaemia and Oxidative Organ Damage in Mice Infected with Plasmodium berghei. Acta Parasit. 69, 242–250 (2024). https://doi.org/10.1007/s11686-023-00741-7
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DOI: https://doi.org/10.1007/s11686-023-00741-7