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In Vivo Therapeutic Effect of Some Medicinal Plants’ Methanolic Extracts on the Growth and Development of Secondary Hydatid Cyst Infection

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Abstract

Purpose

The current study aimed to explore the in vivo therapeutic effects of the methanolic extracts of Citrullus colocynthis, Ruta graveolens, and Peganum harmala against hydatid cyst secondary infection.

Methods

Aerial parts of P. harmala and R. graveolens, including leaves and stems, and seeds of C. colocynthis were collected and extracted using absolute methanol. Rats that are infected with secondary infection of hydatid cysts were treated orally and intraperitoneally according to the determined lethal doses for 30 days. Histological, hematological, and biochemical investigations were done 8 months after the infection.

Results

Compared to Albendazole drug, C. colocynthis, and P. harmala, the methanol extract of R. graveolens showed higher and significant (P < 0.05) therapeutic effects on the secondary hydatid cysts growth. Those effects were represented by the reduction in the cysts’ number, size, and weight; as well as the significant changes (P < 0.05) in values of hematological and biochemical parameters, the elevation of IFN-γ levels, and the decline of IL-10 and IL-4 cytokines, compared to the negative control group in both routes of treatment (oral and IP). Moreover, the histological sections showed that R. graveolens has a clear damaging effect on the hydatid cysts GL in the infected rats represented by the detachment of GL from LL and AL.

Conclusion

This study can open an avenue to find new therapeutics for secondary hydatid cyst infections using the studied plant extracts, especially the extract of R. graveolens.

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Data Availability

All data generated or analyzed during this study are included in this published article.

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Authors and Affiliations

  1. Department of Biological Sciences, Faculty of Science, Mutah University, Mutah, Al-Karak, 61710, Jordan

    Yaseen T. Al Qaisi, Ibrahim I. Alfarrayeh & Ahmad Z. Alsarayreh

  2. Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan

    Khaled M. Khleifat

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  1. Yaseen T. Al Qaisi
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  2. Khaled M. Khleifat
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  3. Ibrahim I. Alfarrayeh
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Contributions

Conceptualization, YA and KK; methodology, KK and YA; formal analysis, all authors; investigation, YA, AA, and IA; resources, all authors; writing—original draft preparation, YA; writing—review and editing, all authors; visualization, all authors; supervision, KK; all authors have read and agreed to the final version of the manuscript.

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Correspondence to Ibrahim I. Alfarrayeh.

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Al Qaisi, Y.T., Khleifat, K.M., Alfarrayeh, I.I. et al. In Vivo Therapeutic Effect of Some Medicinal Plants’ Methanolic Extracts on the Growth and Development of Secondary Hydatid Cyst Infection. Acta Parasit. 67, 1521–1534 (2022). https://doi.org/10.1007/s11686-022-00605-6

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